| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4423287 | B | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as induction of nuclear translocation of mineralocorticoid receptor in absence of aldosterone by receptor translocation assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA4423288 | P | Octanol-water partitioning co-efficient, log D of the compound at pH 7.4 by LC/MS/MS analysis | 52 | small-molecule physicochemical format | Scientific Literature | |||
| 3. | ALA4423290 | B | Displacement of [3H]-aldosterone to human mineralocorticoid receptor LBD by radiometric binding assay | Homo sapiens | 52 | single protein format | Scientific Literature | ||
| 4. | ALA4423291 | B | Binding affinity to recombinant human GR LBD by fluormone GS red-fluorescence polarization assay | Homo sapiens | 47 | single protein format | Scientific Literature | ||
| 5. | ALA4423293 | B | Antagonist activity at gal4-fused human mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 cells by luciferase reporter gene assay | Homo sapiens | 52 | cell-based format | Scientific Literature | ||
| 6. | ALA4423294 | B | Antagonist activity at human gal4-fused mineralocorticoid receptor LBD expressed in UAS-MR-bla HEK293 by luciferase reporter gene assay relative to control | Homo sapiens | 42 | assay format | Scientific Literature | ||
| 7. | ALA4423297 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM measured up to 120 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | cell-based format | Scientific Literature | ||
| 8. | ALA4423298 | B | Antagonist activity at full length human mineralocorticoid receptor expressed in human U2OS cells by luciferase reporter gene assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 9. | ALA4423300 | B | Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assay | Rattus norvegicus | 7 | cell-based format | Scientific Literature | ||
| 10. | ALA4423301 | B | Antagonist activity at gal4-fused rat mineralocorticoid receptor LBD in expressed in human U2OS cells by luciferase reporter gene assay relative to control | Rattus norvegicus | 7 | cell-based format | Scientific Literature | ||
| 11. | ALA4423302 | B | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid receptor in presence of aldosterone by receptor translocation assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 12. | ALA4423303 | B | Modulation activity at human mineralocorticoid receptor in human EA.hy926 cells assessed as blocking of nuclear translocation of mineralocorticoid receptor in presence of aldosterone by receptor translocation assay relative to control | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 13. | ALA4423305 | A | Induction of hyperkalemia in Sprague-Dawley rat fed on low salt diet for 72 hrs assessed as increase in Na+/K+ ratio in urine administered via oral gavage after 8 hrs | Rattus norvegicus | 7 | organism-based format | Scientific Literature | ||
| 14. | ALA4423306 | A | Induction of hyperkalemia in Sprague-Dawley rat fed on low salt diet for 72 hrs assessed as increase in eplerenone-mediated Na+/K+ ratio in urine administered via oral gavage co-administered with after 8 hrs | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 15. | ALA4423307 | A | Fraction unbound in Han Wistar rat plasma at 1 uM after 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 7 | cell-free format | Scientific Literature | ||
| 16. | ALA4423308 | A | Intrinsic clearance in Han Wistar rat hepatocytes assessed per million cells at 1 uM after 4 hrs by LC/MS/MS analysis | Rattus norvegicus | 7 | cell-based format | Scientific Literature | ||
| 17. | ALA4423309 | A | Volume of distribution at steady state in Han Wistar rat at 1.2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 18. | ALA4423312 | A | Clearance in Han Wistar rat at 1.2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 19. | ALA4423315 | A | Terminal half life in Han Wistar rat at 1.2 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 5 | organism-based format | Scientific Literature | ||
| 20. | ALA4423323 | A | Oral bioavailability in Han Wistar rat at 48 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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