| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4307302 | Binding | Inhibition of human recombinant AChE expressed in HEK293 cells using acetylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by spectrophotometry analysis | Homo sapiens | 9 | ALA4304786 | cell-based format | Scientific Literature | |
| 2. | ALA4307303 | Binding | Inhibition of human serum BChE using butyrylthiocholine iodide as substrate preincubated for 20 mins followed by substrate addition by spectrophotometry analysis | Homo sapiens | 9 | ALA4304786 | single protein format | Scientific Literature | |
| 3. | ALA4307304 | Binding | Antagonist activity at NMDA receptor in rat CGN cells assessed as increase in intracellular calcium level incubated for 30 mins in presence of Fura-2AM followed by NMDA/glycine stimulation by fluorescence spectrometer analysis | Rattus norvegicus | 9 | ALA4304786 | cell-based format | Scientific Literature | |
| 4. | ALA4307306 | Binding | Inhibition of human recombinant amyloid beta (1 to 42) aggregation expressed in Escherichia coli BL21 (DE3) at 10 uM by Thioflavin S steady state fluorescence assay relative to control | Homo sapiens | 9 | ALA4304786 | assay format | Scientific Literature | |
| 5. | ALA4307307 | Binding | Inhibition of tau aggregation (unknown origin) expressed in Escherichia coli BL21 (DE3) at 10 uM by Thioflavin S steady state fluorescence assay relative to control | Homo sapiens | 9 | ALA4304786 | assay format | Scientific Literature | |
| 6. | ALA4307308 | ADME | Permeability of the compound measured after compound dilution in PBS/EtOH buffer (70:30) by PAMPA-BBB assay | 23 | ALA4304786 | assay format | Scientific Literature | ||
| 7. | ALA4307311 | Binding | Inhibition of human recombinant BACE-1 expressed in baculovirus expression system at 5 uM using panvera peptide as substrate measured after 1 hr by FRET assay relative to control | Homo sapiens | 9 | ALA4304786 | assay format | Scientific Literature | |
| 8. | ALA4307313 | Binding | Potency index, ratio of IC50 for 6-cholorotacrine to compound IC50 for Inhibition of human recombinant AChE expressed in HEK293 cells | Homo sapiens | 6 | ALA4304786 | cell-based format | Scientific Literature |
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