# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4338413 | B | Inhibition of DPP4 in C57BL/6 mouse serum pre-incubated for 5 mins followed by Gly-Pro-7-AMC substrate addition by fluorescence based assay | Mus musculus | 10 | ALA4334524 | cell-free format | Scientific Literature | |
2. | ALA4338414 | P | Solubility in pH 6.8 buffer by nephelometry | 6 | ALA4334524 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4338415 | P | Solubility in pH 7.4 buffer by nephelometry | 6 | ALA4334524 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4338416 | P | Solubility in pH 7.0 buffer by nephelometry | 6 | ALA4334524 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4338417 | A | Apparent permeability from apical to basolateral side in human Caco2 cells at 20 uM incubated for 1.5 hrs by LC-MS/MS analysis | Homo sapiens | 7 | ALA4334524 | cell-based format | Scientific Literature | |
6. | ALA4338418 | A | Apparent permeability from basolateral to apical side in human Caco2 cells at 20 uM incubated for 1.5 hrs by LC-MS/MS analysis | Homo sapiens | 7 | ALA4334524 | cell-based format | Scientific Literature | |
7. | ALA4338419 | A | Efflux ratio in human Caco2 cells at 20 uM incubated for 1.5 hrs by LC-MS/MS analysis | Homo sapiens | 7 | ALA4334524 | cell-based format | Scientific Literature | |
8. | ALA4338420 | A | Stability in human intestinal S9 fractions assessed as phase I and phase II enzymes-mediated generation of systemic metabolites at 0.1 uM incubated at 37 degC for 10 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4334524 | subcellular format | Scientific Literature | |
9. | ALA4338421 | A | Stability in mouse intestinal S9 fractions assessed as phase I and phase II enzymes-mediated generation of systemic metabolites at 0.1 uM incubated at 37 degC for 10 mins by LC-MS/MS analysis | Mus musculus | 4 | ALA4334524 | subcellular format | Scientific Literature | |
10. | ALA4338422 | A | Inhibition of plasma DPP4 in BALB/c mouse at 30 mg/kg, po after 8 hrs using Gly-Pro-7-AMC substrate by fluorescence based assay | Mus musculus | 3 | ALA4334524 | organism-based format | Scientific Literature | |
11. | ALA4338423 | F | Inhibition of jejunum DPP4 in BALB/c mouse at 30 mg/kg, po after 8 hrs using Gly-Pro-7-AMC substrate by fluorescence based assay | Mus musculus | 3 | ALA4334524 | organism-based format | Scientific Literature | |
12. | ALA4338424 | F | Inhibition of ileum DPP4 in BALB/c mouse at 30 mg/kg, po after 8 hrs using Gly-Pro-7-AMC substrate by fluorescence based assay | Mus musculus | 3 | ALA4334524 | organism-based format | Scientific Literature | |
13. | ALA4338425 | F | Inhibition of colon DPP4 in BALB/c mouse at 30 mg/kg, po after 8 hrs using Gly-Pro-7-AMC substrate by fluorescence based assay | Mus musculus | 3 | ALA4334524 | organism-based format | Scientific Literature | |
14. | ALA4338426 | B | Selectivity index, ratio of IC50 for recombinant human DPP8 to IC50 for inhibition of DPP4 in C57BL/6 mouse serum | 1 | ALA4334524 | assay format | Scientific Literature | ||
15. | ALA4338427 | B | Selectivity index, ratio of IC50 for recombinant human DPP9 to IC50 for inhibition of DPP4 in C57BL/6 mouse serum | 1 | ALA4334524 | assay format | Scientific Literature | ||
16. | ALA4338428 | A | Cytotoxicity in human HepG2 cells assessed as reduction in cell viability up to 200 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA4334524 | cell-based format | Scientific Literature | |
17. | ALA4338429 | A | Cytotoxicity in HEK293 cells assessed as reduction in cell viability up to 200 uM incubated for 24 hrs by MTT assay | Homo sapiens | 1 | ALA4334524 | cell-based format | Scientific Literature | |
18. | ALA4338430 | A | Cytotoxicity in mouse primary hepatocytes assessed as reduction in cell viability up to 200 uM incubated for 24 hrs by MTT assay | Mus musculus | 1 | ALA4334524 | cell-based format | Scientific Literature | |
19. | ALA4338431 | T | Toxicity in ICR mouse assessed as mouse survival at 100 mg/kg, po administered as single dose after 4 days | Mus musculus | 1 | ALA4334524 | organism-based format | Scientific Literature | |
20. | ALA4338432 | T | Toxicity in ICR mouse assessed as effect on body weight at 100 mg/kg, po administered as single dose after 4 days | Mus musculus | 1 | ALA4334524 | organism-based format | Scientific Literature |