# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4433890 | B | Inhibition of human recombinant HDAC1 using ZMAL (Z-(Ac)Lys-AMC fluorogenic substrate incubated for 90 mins by fluorescence method | Homo sapiens | 3 | ALA4433221 | single protein format | Scientific Literature | |
2. | ALA4433891 | B | Inhibition of human recombinant HDAC6 using ZMAL (Z-(Ac)Lys-AMC fluorogenic substrate incubated for 90 mins by fluorescence method | Homo sapiens | 3 | ALA4433221 | single protein format | Scientific Literature | |
3. | ALA4433894 | B | Inhibition of human recombinant HDAC1 using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as residues at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
4. | ALA4433895 | B | Inhibition of human recombinant HDAC2 using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as residues at 10 uM mins by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
5. | ALA4433896 | B | Inhibition of human recombinant HDAC3 using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as residues at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
6. | ALA4433897 | B | Inhibition of human recombinant HDAC4 using fluorogenic trifluoroacetyl lysine as substrate at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
7. | ALA4433898 | B | Inhibition of human recombinant HDAC5 using fluorogenic trifluoroacetyl lysine as substrate at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
8. | ALA4433899 | B | Inhibition of human recombinant HDAC6 using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as residues at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
9. | ALA4433900 | B | Inhibition of human recombinant HDAC7 using fluorogenic trifluoroacetyl lysine as substrate at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
10. | ALA4433901 | B | Inhibition of human recombinant HDAC8 using fluorogenic peptide p53 residues 379-382 (RHK(Ac)K(Ac)AMC) as residues at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
11. | ALA4433902 | B | Inhibition of human recombinant HDAC9 using fluorogenic trifluoroacetyl lysine as substrate at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
12. | ALA4433903 | B | Inhibition of human recombinant HDAC10 using fluorogenic peptide p53 residues 379-382 (RHKK(Ac)AMC) as residues at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
13. | ALA4433904 | B | Inhibition of human recombinant HDAC11 using fluorogenic trifluoroacetyl lysine as substrate at 10 uM by fluorescence method | Homo sapiens | 2 | ALA4433221 | single protein format | Scientific Literature | |
14. | ALA4433905 | A | Permeability of the compound at pH 7.4 PBS buffer at 100 uM measured upto 6 hrs by PAMPA-BBB assay | 10 | ALA4433221 | assay format | Scientific Literature | ||
15. | ALA4433908 | T | Neurotoxicity against rat CGN cells assessed as cell viability at 5 uM incubated for 24 hrs by MTT assay | Rattus norvegicus | 1 | ALA4433221 | cell-based format | Scientific Literature | |
16. | ALA4433909 | B | Inhibition of HDAC in mouse N9 cells assessed as suppression of LPS-induced decrease in histone H3 acetylation at 5 to 25 uM incubated for 24 hrs by Western blot analysis | Mus musculus | 3 | ALA4433221 | cell-based format | Scientific Literature | |
17. | ALA4433910 | F | Immunomodulatory activity in mouse N9 cells assessed as reduction in LPS-induced iNOS expression at 5 to 25 uM incubated for 24 hrs by Western blot analysis | Mus musculus | 3 | ALA4433221 | cell-based format | Scientific Literature | |
18. | ALA4433913 | F | Neuroprotective activity against low serum/K+ deprivation-induced toxicity in rat CGN cells assessed as increase in cell viability at 5 to 25 uM pre-treated for 6 hrs followed by 24 hrs co-treatment with serum/K+ starvation and measured after 24 hrs by MTT assay | Rattus norvegicus | 3 | ALA4433221 | cell-based format | Scientific Literature | |
19. | ALA4433914 | F | Immunomodulatory activity in mouse N9 cells assessed as reduction in LPS-induced MRC1 expression at 5 to 25 uM incubated for 24 hrs by Western blot analysis | Mus musculus | 1 | ALA4433221 | cell-based format | Scientific Literature |