| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4361556 | B | Antagonist activity at TLR4 in mouse BMDM cells assessed as reduction in LPS-induced TNFalpha secretion at 20 to 80 uM after 24 hrs by ELISA | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 2. | ALA4361558 | B | Binding affinity to recombinant human TLR4 using phage displayed compound by Phage-ELISA | Homo sapiens | 6 | ALA4359843 | single protein format | Scientific Literature | |
| 3. | ALA4361559 | A | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 100 uM after 24 hrs by MTT assay | Mus musculus | 5 | ALA4359843 | cell-based format | Scientific Literature | |
| 4. | ALA4361560 | A | Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 20 to 80 uM after 24 hrs by MTT assay | Mus musculus | 5 | ALA4359843 | cell-based format | Scientific Literature | |
| 5. | ALA4361561 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced TNFalpha secretion after 24 hrs by ELISA | Mus musculus | 2 | ALA4359843 | cell-based format | Scientific Literature | |
| 6. | ALA4361562 | B | Antagonist activity at human TLR4 expressed in HEK-Blue cells assessed as reduction in LPS-induced SEAP activity pre-incubated for 1 hr followed by LPS stimulation and measured after 24 hrs by SEAP assay | Homo sapiens | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 7. | ALA4361563 | A | Effect on SEAP activity in HEK-Blue cells harboring human TLR4 at 20 to 80 uM after 1 hr by SEAP assay | Homo sapiens | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 8. | ALA4361564 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced NFkappaB p65 phosphorylation at 80 uM after 15 to 30 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 9. | ALA4361565 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IkappaBalpha cytosolic degradation at 80 uM after 15 to 30 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 10. | ALA4361566 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced ATF3 activation at 80 uM after 120 to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 11. | ALA4361567 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IRF3 phosphorylation at 80 uM after 120 to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 12. | ALA4361568 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced ERK phosphorylation at 80 uM after 15 to 30 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 13. | ALA4361569 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced JNK phosphorylation at 80 uM after 15 to 30 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 14. | ALA4361570 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced p38 phosphorylation at 80 uM after 15 to 30 mins by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 15. | ALA4361571 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced NFkappaB p65 phosphorylation at 80 uM preincubated for 1 hr followed by LPS stimulation and measured after 30 mins by Alexafluor-488/Hoechst 33258 staining based immunofluorescence confocal microscopic method | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 16. | ALA4361572 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IL-6 secretion after 24 hrs by ELISA | Mus musculus | 2 | ALA4359843 | cell-based format | Scientific Literature | |
| 17. | ALA4361573 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced IFNbeta secretion after 24 hrs by ELISA | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 18. | ALA4361574 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced iNOS expression at 80 uM by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 19. | ALA4361575 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced COX2 expression at 80 uM by Western blot analysis | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature | |
| 20. | ALA4361576 | B | Antagonist activity at TLR4 in mouse RAW264.7 cells assessed as reduction in LPS-induced extracellular NO secretion at 20 to 80 uM by spectrophotometric method | Mus musculus | 1 | ALA4359843 | cell-based format | Scientific Literature |
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