# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4419673 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of RhoA-mediated phospho-MLC formation at 10 uM incubated for 24 hrs by densitometry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4419674 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of 10% calf serum-induced RhoA-GTP formation at 10 uM incubated for 24 hrs by densitometry relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4419675 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of RhoA-mediated phospho-MLC formation incubated for 24 hrs by densitometry | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4419676 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4419679 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level at 30 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4419680 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level at 10 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4419681 | B | Inhibition of RhoGEF in human MCF7 cells derived mammospheres assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level at 5 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4419683 | F | Inhibition of cell invasion of human MCF7 cells at 10 to 50 uM by Matrigel-coated transwell based assay | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4419685 | F | Inhibition of cell migration of human MCF7 cells at 10 to 50 uM | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4419687 | F | Growth inhibition of human MCF7 cells at 5 to 50 uM | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4419689 | B | Inhibition of RhoGEF in mouse NIH/3T3 cells assessed as inhibition of 10% calf serum-induced Rac1-GTP formation by measuring relative Rac1-GTP level at 50 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4419691 | B | Inhibition of RhoGEF in mouse NIH/3T3 cells assessed as inhibition of 10% calf serum-induced Cdc42-GTP formation by measuring relative Cdc42-GTP level at 50 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
13. | ALA4419696 | B | Inhibition of RhoGEF in mouse NIH/3T3 cells assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level at 50 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
14. | ALA4419697 | B | Inhibition of RhoGEF in mouse NIH/3T3 cells assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level at 30 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
15. | ALA4419698 | B | Inhibition of RhoGEF in mouse NIH/3T3 cells assessed as inhibition of 10% calf serum-induced RhoA-GTP formation by measuring relative RhoA-GTP level at 10 uM incubated for 24 hrs by densitometry (Rvb = 1 No_unit) | Mus musculus | 2 | cell-based format | Patent Bioactivity Data | ||
16. | ALA4419702 | B | Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 50 uM pull-down assay (Rvb = 1 No unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
17. | ALA4419703 | B | Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 30 uM pull-down assay (Rvb = 1 No unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
18. | ALA4419704 | B | Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 10 uM pull-down assay (Rvb = 1 No unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
19. | ALA4419705 | B | Binding affinity to human LARG (765 to 1138 residues) DH-PH module expressed in mouse NIH/3T3 cells assessed as reduction in LARG binding to human full length RhoA (1 to 193 residues) by measuring relative LARG binding level at 5 uM pull-down assay (Rvb = 1 No unit) | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
20. | ALA4419706 | B | Inhibition of RhoGEF in mouse NIH/3T3 cells assessed as reduction in 10% calf serum-induced rhoA-mediated actin stress fiber formation at 10 uM by rhodamine-phalloidin staining based assay | Mus musculus | 2 | cell-based format | Patent Bioactivity Data |