| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4306826 | B | Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assay | Homo sapiens | 29 | cell-based format | Scientific Literature | ||
| 2. | ALA4306827 | B | Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assay relative to control | Homo sapiens | 28 | cell-based format | Scientific Literature | ||
| 3. | ALA4306828 | P | 1-Octanol/PBS buffer distribution coefficient, log D of the compound at pH 7.4 | 28 | small-molecule physicochemical format | Scientific Literature | |||
| 4. | ALA4306829 | P | Thermodynamic solubility of the compound in aqueous phosphate buffer at pH 7.4 measured after 24 hrs by UPLC-MS/MS-based shake-flask method | 28 | small-molecule physicochemical format | Scientific Literature | |||
| 5. | ALA4306830 | A | Intrinsic clearance in rat hepatocytes assessed per 10'6 cells | Rattus norvegicus | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA4306847 | B | Agonist activity at human His6-tcs-RORalpha LBD assessed as PGC1alpha peptide (130 to 154 residues) recruitment incubated for 1 hr by FRET assay | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 7. | ALA4306849 | B | Agonist activity at RORbeta (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 8. | ALA4306853 | B | Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator peptide measured after 15 mins by FRET assay relative to control | Homo sapiens | 26 | single protein format | Scientific Literature | ||
| 9. | ALA4306854 | B | Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measured after 15 mins by FRET assay | Homo sapiens | 28 | single protein format | Scientific Literature | ||
| 10. | ALA4306855 | B | Agonist activity at RAR alpha (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 11. | ALA4306856 | B | Agonist activity at RAR beta (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA4306857 | B | Agonist activity at RAR gamma (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 13. | ALA4306858 | B | Inverse agonist activity at RORalpha (unknown origin) | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 14. | ALA4833083 | B | Inverse agonist activity at human RORC2 assessed as inhibition of SRC1-derived coactivator peptide by TR-FRET assay | Homo sapiens | 46 | single protein format | Scientific Literature | ||
| 15. | ALA4833084 | F | Suppression of IL-17A production in human Th17 cells incubated for 4 days by IL-17 HTRF assay | Homo sapiens | 48 | cell-based format | Scientific Literature | ||
| 16. | ALA4833085 | A | Metabolic stability in human liver assessed as intrinsic clearance | Homo sapiens | 48 | microsome format | Scientific Literature | ||
| 17. | ALA4833086 | B | Inhibition of human ERG | Homo sapiens | 47 | single protein format | Scientific Literature | ||
| 18. | ALA4833087 | A | Apparent permeability across apical to basolateral side in human Caco-2 cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 19. | ALA4833088 | A | Efflux ratio in human Caco2 cells | Homo sapiens | 15 | cell-based format | Scientific Literature | ||
| 20. | ALA4833089 | A | Intrinsic permeability of compound from apical to basolateral side in human Caco2 cells | Homo sapiens | 15 | cell-based format | Scientific Literature |
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