# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4346578 | Binding | Inhibition of human PRMT6 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
2. | ALA4346579 | Binding | Inhibition of human PRMT6 pre-incubated for 1 to 30 mins using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA4342528 | single protein format | Scientific Literature | |
3. | ALA4346580 | Binding | Inhibition of PRMT6 (unknown origin) assessed as reduction in incorporation of [3H]-labeled methyl group into biotinylated substrate using [3H-SAM] at 10 uM incubated for 1 hr by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
4. | ALA4346581 | Binding | Inhibition of human PRMT6 assessed as Kinact/Ki ratio pre-incubated for 1 to 30 mins using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 1 | ALA4342528 | single protein format | Scientific Literature | |
5. | ALA4346582 | Binding | Time dependent inhibition of human PRMT6 pre-incubated for 1 to 30 mins using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 2 | ALA4342528 | single protein format | Scientific Literature | |
6. | ALA4346584 | Binding | Covalent binding affinity to human PRMT6 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
7. | ALA4346585 | Binding | Covalent binding affinity to human PRMT1 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 1 | ALA4342528 | single protein format | Scientific Literature | |
8. | ALA4346586 | Binding | Covalent binding affinity to human PRMT3 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 1 | ALA4342528 | single protein format | Scientific Literature | |
9. | ALA4346587 | Binding | Covalent binding affinity to human PRMT4 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 1 | ALA4342528 | single protein format | Scientific Literature | |
10. | ALA4346588 | Binding | Covalent binding affinity to human PRMT8 assessed as covalent adduct. formation at 300 uM pre-incubated for 1 hr by mass spectrometry | Homo sapiens | 1 | ALA4342528 | single protein format | Scientific Literature | |
11. | ALA4346589 | Binding | Inhibition of human PRMT1 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
12. | ALA4346590 | Binding | Inhibition of human PRMT3 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
13. | ALA4346591 | Binding | Inhibition of human PRMT4 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
14. | ALA4346592 | Binding | Inhibition of human PRMT8 using [3H]SAM as donor and [3H]methylated biotin-labeled peptide as substrate by scintillation proximity assay | Homo sapiens | 3 | ALA4342528 | single protein format | Scientific Literature | |
15. | ALA4346593 | Binding | Selectivity index, ratio of IC50 for human PRMT3 to IC50 for human PRMT6 | Homo sapiens | 1 | ALA4342528 | assay format | Scientific Literature | |
16. | ALA4346594 | Binding | Selectivity index, ratio of IC50 for human PRMT4 to IC50 for human PRMT6 | Homo sapiens | 1 | ALA4342528 | assay format | Scientific Literature | |
17. | ALA4346595 | Binding | Selectivity index, ratio of IC50 for human PRMT1 to IC50 for human PRMT6 | Homo sapiens | 1 | ALA4342528 | assay format | Scientific Literature | |
18. | ALA4346596 | Binding | Selectivity index, ratio of IC50 for human PRMT8 to IC50 for human PRMT6 | Homo sapiens | 1 | ALA4342528 | assay format | Scientific Literature | |
19. | ALA4346597 | Binding | Inhibition of Flag-tagged PRMT6 (unknown origin) expressed in HEK293 cells incubated for 20 hrs assessed as reduction in H3R2me2a levels | Homo sapiens | 1 | ALA4342528 | cell-based format | Scientific Literature | |
20. | ALA4346600 | Binding | Inhibition of PRMT1 in human MCF7 cells assessed as reduction in H4R3me2a levels incubated for 2 days by fluorescence based assay | Homo sapiens | 2 | ALA4342528 | cell-based format | Scientific Literature |