Antitumor activity against human U118MG cells xenografted in Bar b/c nude mouse assessed as reduction in tumor growth at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured every 3 days for 20 days by caliper method
Antitumor activity against human U118MG cells xenografted in Bar b/c nude mouse assessed as reduction in tumor weight at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured every 3 days for 20 days by caliper method
Toxicity in Bar b/c nude mouse xenografted with human U118MG cells assessed as effect on body weight at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured every 3 days for 20 days
Increase in E-cadherin protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks and measured after 20 days by Western blot analysis
Increase in Bax protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks and measured after 20 days by Western blot analysis
Reduction in STAT3 protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks and measured after 20 days by Western blot analysis
Reduction in vimentin protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks and measured after 20 days by Western blot analysis
Reduction in Bcl2 protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks and measured after 20 days by Western blot analysis
Increase in E-cadherin gene expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks
Reduction in STAT3 gene expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks
Reduction in Bcl2 gene expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered every 3 days for 3 weeks
Antitumor activity against human U118MG cells xenografted in siPKM2-treated Bar b/c nude mouse assessed as tumor growth at 50 mg/kg, ip adminstered twice weekly for 3 weeks measured every 3 days for 20 days by caliper method
Increase in E-cadherin protein expression in tumor of siPKM2-treated Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis
Increase in bax protein expression in tumor of siPKM2-treated Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis
Reduction in vimentin protein expression in tumor of siPKM2-treated Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis
Reduction in phosphorylated STAT3 expression in tumor of siPKM2-treated Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis
Reduction in Bcl2 protein expression in tumor of siPKM2-treated Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis
Permeability in dog MDCK2 cells assessed as reduction in barrier integrity measured within 3 hrs by transendothelial electric resistance measurement assay
Increase in E-cadherin protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis
Increase in bax protein expression in tumor of Bar b/c nude mouse xenografted with human U118MG cells at 50 mg/kg, ip adminstered twice weekly for 3 weeks and measured after 20 days by immunohistochemical analysis