# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4403231 | B | Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 20 mins followed by substrate addition by ROS-Glo assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
2. | ALA4403232 | B | Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay | Homo sapiens | 38 | cell-based format | Scientific Literature | ||
3. | ALA4403233 | B | Inhibition of human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 3 hrs followed by substrate addition by ROS-Glo assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
4. | ALA4403234 | B | Ratio of IC50 for human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 20 mins followed by substrate addition to IC50 for human C-terminal His10-tagged LOXL2 (Met1 to Gln774 residues) expressed in mouse NS0 cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
5. | ALA4403236 | B | Inhibition of pig skin-derived LOX using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay | Sus scrofa | 11 | assay format | Scientific Literature | ||
6. | ALA4403237 | B | Inhibition of recombinant C-terminal His-tagged human LOXL3 (1 to 753 residues) expressed in CHO cells using cadaverine hydrochloride as substrate preincubated for 1 hr followed by substrate addition by ROS-Glo assay | Homo sapiens | 11 | cell-based format | Scientific Literature | ||
7. | ALA4403239 | B | Inhibition of recombinant human MAOA expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
8. | ALA4403240 | B | Inhibition of recombinant human MAOB expressed in baculovirus infected BTI insect cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
9. | ALA4403241 | B | Inhibition of porcine kidney DAO measured after 1 hrs by ROS-glo assay | Sus scrofa | 10 | single protein format | Scientific Literature | ||
10. | ALA4403242 | B | Inhibition of recombinant human SSAO expressed in CHO cells using luminogenic MAO substrate measured after 1 hr by MAO-glo assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
11. | ALA4403243 | B | Inhibition of human ERG expressed in CHOK1 cells by Qpatch electrophysiological assay | Homo sapiens | 10 | cell-based format | Scientific Literature | ||
12. | ALA4403244 | A | Stability in CD1 mouse liver microsomes assessed as parent compound remaining at 10 uM measured after 30 mins by LC-MS/MS analysis | Mus musculus | 7 | microsome format | Scientific Literature | ||
13. | ALA4403246 | A | Cmax in mouse at 50 mg/kg, po administered as single dose via gavage | Mus musculus | 7 | organism-based format | Scientific Literature | ||
14. | ALA4403247 | A | AUC in mouse at 50 mg/kg, po administered as single dose via gavage | Mus musculus | 7 | organism-based format | Scientific Literature | ||
15. | ALA4403248 | A | Half life in mouse at 50 mg/kg, po administered as single dose via gavage | Mus musculus | 7 | organism-based format | Scientific Literature | ||
16. | ALA4403249 | A | Oral bioavailability in mouse at 50 mg/kg administered as single dose via gavage | Mus musculus | 7 | organism-based format | Scientific Literature | ||
17. | ALA4403254 | A | Apparent permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
18. | ALA4403255 | A | Apparent permeability across basolateral to apical side in human Caco2 cells | Homo sapiens | 7 | cell-based format | Scientific Literature |