| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4313811 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as reduction in parasite load at 40 mg/kg/day, po for 10 days formulated with 8% v/v DMSO relative to control | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 2. | ALA4313812 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as reduction in parasite load at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin relative to control | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 3. | ALA4313813 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as reduction in parasite load at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin relative to control | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 4. | ALA4313814 | A | Binding affinity to human serum albumin by fluorescence based assay | Homo sapiens | 1 | ALA4311972 | single protein format | Scientific Literature | |
| 5. | ALA4313815 | A | Binding affinity to bovine serum albumin by fluorescence based assay | Bos taurus | 1 | ALA4311972 | single protein format | Scientific Literature | |
| 6. | ALA4313816 | U | Chemical stability of compound in PBS at 20 uM at pH 8 exposed to 2-mins nitrogen bubbling followed by supplementation with human serum albumin measured for 6 hrs by UV-vis spectrophotometry analysis | 1 | ALA4311972 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4313817 | U | Chemical stability of compound in PBS at 20 uM at pH 8 exposed to air bubbling followed by supplementation with human serum albumin measured for 6 hrs by UV-vis spectrophotometry analysis | 1 | ALA4311972 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4313818 | P | Chemical stability of compound in PBS assessed as decrease in absorbance at 60 uM at pH 7 to 8 and 25 degC measured within 50 mins under dark conditions by UV-vis spectrophotometry analysis | 1 | ALA4311972 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4313819 | P | Chemical stability of compound in PBS assessed as decrease in absorbance at 60 uM at pH 7 to 8 and 25 degC measured within 20 mins under dark conditions by UV-vis spectrophotometry analysis | 1 | ALA4311972 | small-molecule physicochemical format | Scientific Literature | ||
| 10. | ALA4313820 | P | Chemical stability of compound in DMSO at 60 uM assessed as drug degradation measured at room temperature in dark after 1 day by UV-vis spectrophotometric analysis | 1 | ALA4311972 | small-molecule physicochemical format | Scientific Literature | ||
| 11. | ALA4313821 | A | Plasma concentration in syrian hamster infected with Leishmania infantum BCN150 promastigote at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin | Mesocricetus auratus | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 12. | ALA4313822 | A | Plasma concentration in syrian hamster infected with Leishmania infantum BCN150 promastigote at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin | Mesocricetus auratus | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 13. | ALA4313823 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within liver at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin (Rvb = 5000000.000 +/- 1673320.053/g) | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 14. | ALA4313824 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within liver at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin (Rvb = 4333333.333 +/- 3444802.849 /g) | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 15. | ALA4313825 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within spleen at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin (Rvb = 8508698.676 +/- 2835609.487/g) | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 16. | ALA4313826 | F | Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within spleen at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin (Rvb = 9874032.937 +/- 3482270.184/g) | Leishmania infantum | 1 | ALA4311972 | organism-based format | Scientific Literature | |
| 17. | ALA4313828 | F | Antileishmanial activity against luciferase expressing intracellular amastigote stage of Leishmania infantum infected in human THP1 cells assessed as parasite growth inhibition measured after 48 to 72 hrs by steady-glo luciferase assay | Leishmania infantum | 19 | ALA4311972 | organism-based format | Scientific Literature | |
| 18. | ALA4313829 | F | Antitrypanosomal activity against intracellular amastigote stage of Trypanosoma cruzi Silvio X10/1 infected in human U2OS cells measured after 96 hrs by DRAQ5 dye based microscopic analysis | Trypanosoma cruzi | 3 | ALA4311972 | organism-based format | Scientific Literature | |
| 19. | ALA4313830 | F | Antitrypanosomal activity against Trypanosoma brucei bloodstream form assessed as parasite growth inhibition incubated for 72 hrs by resazurin dye based assay | Trypanosoma brucei | 39 | ALA4311972 | organism-based format | Scientific Literature | |
| 20. | ALA4313831 | F | Antileishmanial activity against promastigote form of Leishmania donovani assessed as parasite growth inhibition | Leishmania donovani | 2 | ALA4311972 | organism-based format | Scientific Literature |
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