Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as reduction in parasite load at 40 mg/kg/day, po for 10 days formulated with 8% v/v DMSO relative to control
Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as reduction in parasite load at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin relative to control
Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as reduction in parasite load at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin relative to control
Chemical stability of compound in PBS at 20 uM at pH 8 exposed to 2-mins nitrogen bubbling followed by supplementation with human serum albumin measured for 6 hrs by UV-vis spectrophotometry analysis
Chemical stability of compound in PBS at 20 uM at pH 8 exposed to air bubbling followed by supplementation with human serum albumin measured for 6 hrs by UV-vis spectrophotometry analysis
Chemical stability of compound in PBS assessed as decrease in absorbance at 60 uM at pH 7 to 8 and 25 degC measured within 50 mins under dark conditions by UV-vis spectrophotometry analysis
Chemical stability of compound in PBS assessed as decrease in absorbance at 60 uM at pH 7 to 8 and 25 degC measured within 20 mins under dark conditions by UV-vis spectrophotometry analysis
Chemical stability of compound in DMSO at 60 uM assessed as drug degradation measured at room temperature in dark after 1 day by UV-vis spectrophotometric analysis
Plasma concentration in syrian hamster infected with Leishmania infantum BCN150 promastigote at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin
Plasma concentration in syrian hamster infected with Leishmania infantum BCN150 promastigote at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin
Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within liver at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin (Rvb = 5000000.000 +/- 1673320.053/g)
Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within liver at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin (Rvb = 4333333.333 +/- 3444802.849 /g)
Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within spleen at 40 mg/kg/day, po for 10 days formulated with 50% v/v cyclodextrin (Rvb = 8508698.676 +/- 2835609.487/g)
Antileishmanial activity against Leishmania infantum amastigotes infected in Syrian hamster assessed as parasite load within spleen at 40 mg/kg/day, po for 10 days formulated with 30% v/v cyclodextrin (Rvb = 9874032.937 +/- 3482270.184/g)
Antileishmanial activity against luciferase expressing intracellular amastigote stage of Leishmania infantum infected in human THP1 cells assessed as parasite growth inhibition measured after 48 to 72 hrs by steady-glo luciferase assay
Antitrypanosomal activity against intracellular amastigote stage of Trypanosoma cruzi Silvio X10/1 infected in human U2OS cells measured after 96 hrs by DRAQ5 dye based microscopic analysis
Antitrypanosomal activity against Trypanosoma brucei bloodstream form assessed as parasite growth inhibition incubated for 72 hrs by resazurin dye based assay