| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4332212 | F | Antagonist activity at recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay | Homo sapiens | 50 | ALA4330105 | cell-based format | Scientific Literature | |
| 2. | ALA4332213 | P | High throughput equilibrium kinetic solubility at pH 7 | 40 | ALA4330105 | small-molecule physicochemical format | Scientific Literature | ||
| 3. | ALA4332214 | B | Antagonist activity at CCR1 in human THP1 cells assessed as inhibition of chemotaxis after 30 mins by Celltiter-glo reagent based luminescence assay | Homo sapiens | 3 | ALA4330105 | cell-based format | Scientific Literature | |
| 4. | ALA4332215 | A | Clearance in human liver microsomes relative to hepatic blood flow | Homo sapiens | 3 | ALA4330105 | microsome format | Scientific Literature | |
| 5. | ALA4332216 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 3 | ALA4330105 | single protein format | Scientific Literature | |
| 6. | ALA4332217 | B | Inhibition of human ERG by patch clamp method | Homo sapiens | 3 | ALA4330105 | assay format | Scientific Literature | |
| 7. | ALA4332219 | P | Thermodynamic solubility of the compound at pH 7 using crystalline sample | 3 | ALA4330105 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4332221 | B | Inhibition of MIP1alpha-stimulated CCR1 internalization in human whole blood preincubated for 30 mins followed by MIP1alpha-stimulation and measured after 40 mins by Alexa647 staining based FACS analysis | Homo sapiens | 2 | ALA4330105 | tissue-based format | Scientific Literature | |
| 9. | ALA4332222 | F | Antagonist activity at mouse CCR1 assessed as inhibition of MIP-1 alpha-induced calcium flux by Fluo-4 NW or Calcium 4 dye based FLIPR TETRA assay | Mus musculus | 2 | ALA4330105 | single protein format | Scientific Literature | |
| 10. | ALA4332223 | B | Selectivity ratio of IC50 for mouse CCR1 to IC50 for recombinant CCR1 (unknown origin) expressed in non-adherent cells co-expressing Galpha16 | 2 | ALA4330105 | cell-based format | Scientific Literature | ||
| 11. | ALA4332224 | A | Clearance in hepatocytes (unknown origin) relative to hepatic blood flow | Not specified | 2 | ALA4330105 | cell-based format | Scientific Literature | |
| 12. | ALA4332228 | F | Antiarthritic activity in collagen antibody-induced arthritis mouse model assessed as reduction in disease severity score at 100 mg/kg bid measured on day 14 relative to control | Mus musculus | 1 | ALA4330105 | organism-based format | Scientific Literature | |
| 13. | ALA4332229 | F | Antiarthritic activity in collagen antibody-induced arthritis mouse model assessed as reduction in disease severity score at 30 mg/kg bid measured on day 14 relative to control | Mus musculus | 1 | ALA4330105 | organism-based format | Scientific Literature | |
| 14. | ALA4332230 | A | Ratio of plasma concentration in mouse model of collagen antibody-induced arthritis at 100 mg/kg bid to IC50 for MIP1alpha-stimulated CCR1 internalization in mouse whole blood | 1 | ALA4330105 | organism-based format | Scientific Literature | ||
| 15. | ALA4332231 | F | Antiarthritic activity in collagen antibody-induced arthritis mouse model assessed as improvement in fore paw histology score by histopathological analysis | Mus musculus | 1 | ALA4330105 | organism-based format | Scientific Literature | |
| 16. | ALA4332232 | T | Toxicity in dog assessed as bone marrow ablation | Canis lupus familiaris | 1 | ALA4330105 | assay format | Scientific Literature | |
| 17. | ALA4332233 | F | Ex vivo inhibition of CCR1 receptor internalization in dog neutrophils at 1 mg/kg/day measured for 4 week | Canis lupus familiaris | 1 | ALA4330105 | organism-based format | Scientific Literature | |
| 18. | ALA4332234 | T | Toxicity in dog assessed as decrease in peripheral leukocyte at 5 mg/kg/day measured for 8 days | Canis lupus familiaris | 1 | ALA4330105 | organism-based format | Scientific Literature | |
| 19. | ALA4332235 | T | Toxicity in dog assessed as change in T-cells at 5 mg/kg/day measured for 8 days | Canis lupus familiaris | 1 | ALA4330105 | organism-based format | Scientific Literature | |
| 20. | ALA4332236 | T | Toxicity in dog assessed as decrease in peripheral leukocyte at 1 mg/kg/day measured for 8 days | Canis lupus familiaris | 1 | ALA4330105 | organism-based format | Scientific Literature |
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