# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4395918 | B | Inhibition of human topoisomerase 2alpha using supercoiled pNO1 plasmid as substrate after 30 mins by HTS assay | Homo sapiens | 39 | single protein format | Scientific Literature | ||
2. | ALA4395919 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 3.9 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
3. | ALA4395920 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 31.5 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
4. | ALA4395921 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 125 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
5. | ALA4395922 | B | Inhibition of human topoisomerase-2alpha mediated decatenation at 500 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
6. | ALA4395923 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 3.9 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
7. | ALA4395924 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 31.5 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
8. | ALA4395925 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 125 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
9. | ALA4395926 | B | Inhibition of human topoisomerase-2beta mediated decatenation at 500 uM using kinetoplast DNA as substrate after 30 mins in presence of ATP by ethidium bromide staining-based gel electrophoresis method relative to control | Homo sapiens | 4 | single protein format | Scientific Literature | ||
10. | ALA4395927 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 3.9 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
11. | ALA4395928 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 31.5 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
12. | ALA4395929 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 125 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
13. | ALA4395930 | A | Poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 500 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 8.11 %) | Homo sapiens | 4 | single protein format | Scientific Literature | ||
14. | ALA4395931 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 3.9 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
15. | ALA4395932 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 31.5 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
16. | ALA4395933 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 125 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
17. | ALA4395934 | B | Inhibition of etoposide induced poison activity at human topoisomerase-2alpha assessed as linear DNA formation at 500 uM using supercoiled pBR322 DNA as substrate after 60 mins by ethidium bromide staining based agarose gel electrophoresis method (Rvb = 35.56 microM/min) | Homo sapiens | 3 | single protein format | Scientific Literature | ||
18. | ALA4395972 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability at 200 uM after 24 hrs by MTS assay relative to control | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
19. | ALA4395973 | F | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability at 200 uM after 24 hrs by MTS assay relative to control | Homo sapiens | 12 | cell-based format | Scientific Literature | ||
20. | ALA4395974 | F | Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 24 hrs by MTS assay | Homo sapiens | 12 | cell-based format | Scientific Literature |