| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4433135 | B | Antagonist activity against human EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by ELISA | Homo sapiens | 21 | ALA4431394 | single protein format | Scientific Literature | |
| 2. | ALA4433136 | A | Half life in mouse plasma assessed as remaining peptide antagonistic activity for inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc incubated for 3 days by ELISA | Mus musculus | 21 | ALA4431394 | cell-free format | Scientific Literature | |
| 3. | ALA4433137 | B | Binding affinity to 6His-tagged EphA4 C204A mutant (29 to 104 residues) (unknown origin) expressed in Escherichia coli Origami 2 (DE3) by isothermal titration calorimetry | Homo sapiens | 7 | ALA4431394 | assay format | Scientific Literature | |
| 4. | ALA4433138 | B | Inhibition of 0.5 ug/ml ephrinA5-induced human EphA4 tyrosine phosphorylation expressed in HEK293AD cells preincubated for 20 mins followed by ephrinA5 stimulation for 20 mins by immunoblot analysis | Homo sapiens | 1 | ALA4431394 | cell-based format | Scientific Literature | |
| 5. | ALA4433139 | F | Inhibition of ephrinA5-induced growth cone collapse in chicken embryo retinal explants at 150 nM preincubated for 30 mins followed by ephrinA5 stimulation for 30 mins by rhodamine-conjugated phalloidin staining based assay | Gallus gallus | 1 | ALA4431394 | tissue-based format | Scientific Literature | |
| 6. | ALA4433140 | B | Antagonist activity against mouse EphA4 receptor assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by ELISA | Mus musculus | 1 | ALA4431394 | single protein format | Scientific Literature | |
| 7. | ALA4433141 | A | Stability in Sprague-Dawley rat CSF assessed as remaining peptide antagonistic activity for inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc incubated for 3 days by ELISA | Rattus norvegicus | 2 | ALA4431394 | tissue-based format | Scientific Literature | |
| 8. | ALA4433142 | B | Selectivity ratio of IC50 for EphA2 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 9. | ALA4433143 | B | Selectivity ratio of IC50 for EphA3 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 10. | ALA4433144 | B | Selectivity ratio of IC50 for EphA5 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 11. | ALA4433145 | B | Selectivity ratio of IC50 for EphA6 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 12. | ALA4433146 | B | Selectivity ratio of IC50 for EphA7 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 13. | ALA4433147 | B | Selectivity ratio of IC50 for EphA8 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 14. | ALA4433148 | B | Selectivity ratio of IC50 for EphB1 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 15. | ALA4433149 | B | Selectivity ratio of IC50 for EphB2 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 16. | ALA4433150 | B | Selectivity ratio of IC50 for EphB3 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 17. | ALA4433151 | B | Selectivity ratio of IC50 for EphB4 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 18. | ALA4433152 | B | Selectivity ratio of IC50 for EphB6 (unknown origin) to IC50 for human EphA4 | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature | |
| 19. | ALA4433153 | A | Cytotoxicity against mouse HT22 cells at 15 to 30 uM after 24 hrs by MTT assay | Mus musculus | 2 | ALA4431394 | cell-based format | Scientific Literature | |
| 20. | ALA4433155 | B | Antagonist activity against EphA4 receptor E77A mutant (unknown origin) expressed in Escherichia coli Origami 2 (DE3) assessed as inhibition of binding of alkaline phosphatase-fused ephrin-A5 to immobilized EphA4 Fc by ELISA | Homo sapiens | 1 | ALA4431394 | assay format | Scientific Literature |
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