# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4392600 | A | Prodrug activation in pH 7.4 PBS buffer assessed as 3.3 ug/mL NADPH-cytochrome P450 reductase (unknown origin) mediated FdUrd formation at 0.62 mM in the presence of beta-NADPH measured after 2 hrs under hypoxic condition by reverse phase HPLC relative to control | Homo sapiens | 2 | single protein format | Scientific Literature | ||
2. | ALA4392601 | A | Prodrug activation in pH 7.4 PBS buffer assessed as 3.3 ug/mL NADPH-cytochrome P450 reductase (unknown origin) mediated FdUrd formation at 0.62 mM in the presence of beta-NADPH measured after 2 hrs under aerobic condition by reverse phase HPLC | Homo sapiens | 1 | single protein format | Scientific Literature | ||
3. | ALA4392603 | A | Prodrug conversion in pH 7.4 PBS buffer assessed as NADPH-cytochrome P450 reductase (unknown origin) mediated FdUrd release by measuring Vmax at 0.62 mM in the presence of beta-NADPH measured after 2 hrs under hypoxic condition by Lineweaver-Burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
4. | ALA4392604 | A | Prodrug conversion in pH 7.4 PBS buffer assessed as NADPH-cytochrome P450 reductase (unknown origin) mediated FdUrd release by measuring Vmax at 0.62 mM in the presence of beta-NADPH measured after 2 hrs under aerobic condition by Lineweaver-Burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
5. | ALA4392605 | A | Prodrug conversion in pH 7.4 PBS buffer assessed as NADPH-cytochrome P450 reductase (unknown origin) mediated FdUrd release by measuring Km at 0.62 mM in the presence of beta-NADPH measured after 2 hrs under hypoxic condition by Lineweaver-Burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
6. | ALA4392606 | A | Prodrug conversion in pH 7.4 PBS buffer assessed as NADPH-cytochrome P450 reductase (unknown origin) mediated FdUrd release by measuring Km at 0.62 mM in the presence of beta-NADPH measured after 2 hrs under aerobic condition by Lineweaver-Burk plot analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
7. | ALA4392607 | A | Prodrug conversion in PBS/t-BuOH solution assessed as semiquinone radical formation at 200 uM under hypoxic condition by pulse radiolysis | 1 | assay format | Scientific Literature | |||
8. | ALA4392608 | F | Cytotoxicity against human A549 cells at 1 to 50 uM treated 24 hrs post hypoxic condition measured after 72 hrs under hypoxic condition by WST-8 assay relative to control | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
9. | ALA4392609 | A | Cytotoxicity against human A549 cells at 1 uM treated 24 hrs post aerobic condition and measured after 72 hrs under aerobic condition by WST-8 assay relative to control | Homo sapiens | 2 | cell-based format | Scientific Literature |