1. ALA4397084 A Activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring LTR driven CBG reporter co-expressing CMV driven CBR reporter assessed as CMV driven gene expression at 40 uM incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay Homo sapiens 6 ALA4396867 cell-based format Scientific Literature 2. ALA4397085 A Activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as CMV driven gene expression incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay Homo sapiens 102 ALA4396867 cell-based format Scientific Literature 3. ALA4397086 B Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as LTR-driven gene expression incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay Human immunodeficiency virus 1 102 ALA4396867 cell-based format Scientific Literature 4. ALA4397095 A Cytotoxicity against human HepG2 cells assessed as reduction in cell growth incubated for 48 hrs by CellTiter-Glo assay Homo sapiens 14 ALA4396867 cell-based format Scientific Literature 5. ALA4397096 A Cytotoxicity against HEK293 cells assessed as reduction in cell growth incubated for 48 hrs by MTS assay Homo sapiens 14 ALA4396867 cell-based format Scientific Literature 6. ALA4397098 B Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as maximum LTR activity at 5 uM incubated for 48 hr using Chroma-Glo substrate by luciferase dual reporter cellular assay relative to control Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 7. ALA4397105 B Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as LTR-driven gene expression incubated for 48 hr by FACSCalibur flow cytometry Human immunodeficiency virus 1 14 ALA4396867 cell-based format Scientific Literature 8. ALA4397106 A Activation of non-specific gene expression in human J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as CMV driven gene expression incubated for 48 hr by FACSCalibur flow cytometry Homo sapiens 14 ALA4396867 cell-based format Scientific Literature 9. ALA4397125 B Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of Ricolinostat Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 10. ALA4397126 B Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of Ricolinostat Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 11. ALA4397127 B Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of JQ1 Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 12. ALA4397128 B Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of PFI-1 Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 13. ALA4397129 B Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of JQ1 Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 14. ALA4397130 B Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of PFI-1 Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 15. ALA4397131 B Synergistic activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells at 10 uM incubated for 48 hrs in presence of DZNep relative to compound alone Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 16. ALA4397132 B Activation of Tat-mediated HIV1 transcription in CD4 positive cells derived from HIV-infected patient on suppressive anti-retroviral therapy assessed as increase in unspliced HIV transcripts at 2.5 uM incubated for 72 hrs by RT-qPCR method relative to control Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature 17. ALA4397133 B Synergistic activation of Tat-mediated HIV1 transcription in in CD4 positive cells derived from HIV-infected patient on suppressive anti-retroviral therapy at 2.5 uM incubated for 72 hrs in presence of JQ1 Human immunodeficiency virus 1 1 ALA4396867 cell-based format Scientific Literature 18. ALA4397135 T Selectivity ratio of EC50 for activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as CMV driven gene expression to EC50 for activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harboring LTR driven CBR reporter co-expressing CMV driven CBG reporter assessed as LTR-driven gene expression 13 ALA4396867 cell-based format Scientific Literature 19. ALA4397136 B Activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells harboring LTR driven GFP reporter co-expressing CMV driven RFP reporter assessed as maximum LTR activity at 20 uM incubated for 48 hr by FACSCalibur flow cytometry relative to control Human immunodeficiency virus 1 6 ALA4396867 cell-based format Scientific Literature 20. ALA4397143 B Synergistic activation of Tat-mediated HIV1 transcription in J-Lat 10.6 cells at 10 uM incubated for 48 hrs in presence of DZNep Human immunodeficiency virus 1 2 ALA4396867 cell-based format Scientific Literature