# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4326666 | F | Antiinflammatory activity in ICR mouse primary peritoneal macrophages assessed as inhibition of LPS-induced IL-6 production at 20 uM preincubated for 60 mins followed by LPS stimulation and measured after 24 hrs by ELISA relative to control | Mus musculus | 48 | ALA4325844 | cell-based format | Scientific Literature | |
2. | ALA4326667 | F | Antiinflammatory activity in ICR mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha production at 20 uM preincubated for 60 mins followed by LPS stimulation and measured after 24 hrs by ELISA relative to control | Mus musculus | 48 | ALA4325844 | cell-based format | Scientific Literature | |
3. | ALA4326668 | F | Antiinflammatory activity in ICR mouse primary peritoneal macrophages assessed as inhibition of LPS-induced IL-6 production preincubated for 2 hrs followed by LPS stimulation and measured after 22 hrs by ELISA | Mus musculus | 4 | ALA4325844 | cell-based format | Scientific Literature | |
4. | ALA4326669 | F | Antiinflammatory activity in ICR mouse primary peritoneal macrophages assessed as inhibition of LPS-induced TNFalpha production preincubated for 2 hrs followed by LPS stimulation and measured after 22 hrs by ELISA | Mus musculus | 4 | ALA4325844 | cell-based format | Scientific Literature | |
5. | ALA4326674 | B | Inhibition of LPS-induced HA-tagged MyD88 (unknown origin) interaction with FLAG-tagged MyD88 (unknown origin) expressed in HEK293 cells at 20 uM after 48 hrs by co-immunoprecipitation method | Homo sapiens | 2 | ALA4325844 | cell-based format | Scientific Literature | |
6. | ALA4326677 | B | Binding affinity to recombinant human MyD88 TIR domain (157 to 296 residues) expressed in Escherichia coli BL21(DE3) by surface plasmon resonance analysis | Homo sapiens | 2 | ALA4325844 | assay format | Scientific Literature | |
7. | ALA4326680 | B | Inhibition of MyD88 in ICR mouse primary peritoneal macrophages assessed as reduction in LPS-induced JNK phosphorylation at 20 uM preincubated for 30 mins followed by LPS-stimulation and measured after 20 mins by Western blot analysis | Mus musculus | 2 | ALA4325844 | single protein format | Scientific Literature | |
8. | ALA4326681 | B | Inhibition of MyD88 in ICR mouse primary peritoneal macrophages assessed as reduction in LPS-induced ERK phosphorylation at 20 uM preincubated for 30 mins followed by LPS-stimulation and measured after 20 mins by Western blot analysis | Mus musculus | 2 | ALA4325844 | single protein format | Scientific Literature | |
9. | ALA4326682 | B | Inhibition of MyD88 in ICR mouse primary peritoneal macrophages assessed as reduction in LPS-induced p38 MAPK phosphorylation at 20 uM preincubated for 30 mins followed by LPS-stimulation and measured after 20 mins by Western blot analysis | Mus musculus | 2 | ALA4325844 | single protein format | Scientific Literature | |
10. | ALA4326687 | F | Antiinflammatory activity in LPS-induced C57/BL6 mouse model of acute lung injury assessed as reduction in lung wet/dry ratio at 10 mg/kg, ip pretreated for 30 mins followed by LPS challenge measured after 6 hrs | Mus musculus | 2 | ALA4325844 | organism-based format | Scientific Literature | |
11. | ALA4326688 | F | Antiinflammatory activity in LPS-induced C57/BL6 mouse model of acute lung injury assessed as reduction in IL6 level in BALF at 10 mg/kg, ip pretreated for 30 mins followed by LPS challenge measured after 6 hrs by ELISA | Mus musculus | 2 | ALA4325844 | organism-based format | Scientific Literature | |
12. | ALA4326689 | F | Antiinflammatory activity in LPS-induced C57/BL6 mouse model of acute lung injury assessed as reduction in TNFalpha level in BALF at 10 mg/kg, ip pretreated for 30 mins followed by LPS challenge measured after 6 hrs by ELISA | Mus musculus | 2 | ALA4325844 | organism-based format | Scientific Literature | |
13. | ALA4326690 | F | Antiinflammatory activity in LPS-induced C57/BL6 mouse model of acute lung injury assessed as reduction in IL6 level in serum at 10 mg/kg, ip pretreated for 30 mins followed by LPS challenge measured after 6 hrs by ELISA | Mus musculus | 2 | ALA4325844 | organism-based format | Scientific Literature | |
14. | ALA4326691 | F | Antiinflammatory activity in LPS-induced C57/BL6 mouse model of acute lung injury assessed as reduction in TNFalpha level in serum at 10 mg/kg, ip pretreated for 30 mins followed by LPS challenge measured after 6 hrs by ELISA | Mus musculus | 2 | ALA4325844 | organism-based format | Scientific Literature | |
15. | ALA5231485 | B | Inhibition of recombinant human MMP-2 using QF24 as substrate incubated for 3 hrs by spectrofluorometer assay | Homo sapiens | 2 | ALA5230116 | single protein format | Scientific Literature | |
16. | ALA5231486 | B | Inhibition of recombinant human MMP-8 using QF24 as substrate incubated for 3 hrs by spectrofluorometer assay | Homo sapiens | 2 | ALA5230116 | single protein format | Scientific Literature |