# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4396682 | F | Antiviral activity against influenza A virus A/Duck/Guangdong/99(H5N1) infected in MDCK cells assessed as reduction in virus induced cytopathic effect preincubated for 30 mins with virus followed by viral infection and measured after 48 hrs by microscopy analysis | Influenza A virus | 16 | ALA4393734 | organism-based format | Scientific Literature | |
2. | ALA4396683 | A | Cytotoxicity against dog MDCK cells measured after 48 hrs by MTT assay | Canis lupus familiaris | 16 | ALA4393734 | cell-based format | Scientific Literature | |
3. | ALA4396684 | T | Selectivity index, ratio of CC50 for dog MDCK cells to IC50 for influenza A virus A/Duck/Guangdong/99(H5N1) | 16 | ALA4393734 | assay format | Scientific Literature | ||
4. | ALA4396685 | F | Antiviral activity against influenza A virus A/Duck/Guangdong/99(H5N1) infected in MDCK cells assessed as inhibition of viral replication measured after 48 hr post infection by FITC/DAPI-staining based immunofluorescence microscopy assay | Influenza A virus | 1 | ALA4393734 | organism-based format | Scientific Literature | |
5. | ALA4396686 | F | Antiviral activity against influenza A virus H5N1 pseudovirus with HA (A/Thailand/Kan353/2004(H5N1) - HA/NA (A/Thailand/Kan353/2004(H5N1) -NA/HIV core plasmids infected in MDCK cells assessed as pseudovirus neutralization incubated for 30 mins with virus followed by viral infection and measured after 48 hrs by luciferase assay | Influenza A virus | 1 | ALA4393734 | organism-based format | Scientific Literature | |
6. | ALA4396687 | B | Inhibition of Influenza A virus (A/Puerto Rico/8/34(H1N1) neuraminidase N1 using MUNANA as substrate preincubated for 30 mins followed by substrate addition and further incubated for 1 hr in dark by microplate reader based fluorescence assay | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | 3 | ALA4393734 | single protein format | Scientific Literature | |
7. | ALA4396688 | B | Inhibition of influenza A virus HA-mediated chicken erythrocytes hemagglutination measured after 1 hr | Influenza A virus | 1 | ALA4393734 | assay format | Scientific Literature | |
8. | ALA4396689 | B | Binding affinity to influenza A virus hemagglutin by surface plasmon resonance assay | Influenza A virus | 1 | ALA4393734 | single protein format | Scientific Literature | |
9. | ALA4396690 | B | Binding affinity to influenza A virus hemagglutinin 1 by surface plasmon resonance assay | Influenza A virus | 1 | ALA4393734 | assay format | Scientific Literature | |
10. | ALA4396691 | F | Antiviral activity against VSV-G pseudovirus infected in MDCK cells assessed as pseudovirus neutralization preincubated for 30 mins with virus and followed by viral infection and measured after 48 hrs by luciferase assay | Vesicular stomatitis virus | 1 | ALA4393734 | organism-based format | Scientific Literature | |
11. | ALA5115061 | B | Binding affinity to SARS-CoV-2 Spike trimer protein by SPR analysis | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5113397 | single protein format | Scientific Literature | |
12. | ALA5115064 | F | Antiviral activity against pseudovirus SARS-CoV-2 spike protein infected human HEK293T cells overexpressing ACE2 assessed as inhibition on pseudovirus infection incubated for 48 hrs by luciferase assay | Severe acute respiratory syndrome coronavirus 2 | 5 | ALA5113397 | organism-based format | Scientific Literature | |
13. | ALA5115065 | F | Antiviral activity against SARS-CoV-2 VSV-G pseudotyped virus infected human HEK293T cells overexpressing ACE2 incubated for 48 hrs by luciferase assay | Severe acute respiratory syndrome coronavirus 2 | 4 | ALA5113397 | organism-based format | Scientific Literature | |
14. | ALA5115066 | T | Cytotoxicity against human HEK293T cells overexpressing human ACE2 assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Homo sapiens | 4 | ALA5113397 | cell-based format | Scientific Literature | |
15. | ALA5115067 | T | Selectivity index, ratio of CC50 for cytotoxicity against human HEK293T cells overexpressing human ACE2 to EC50 for antiviral activity against SARS-CoV-2 VSV-G pseudotyped virus infected human HEK293T cells overexpressing ACE2 | 4 | ALA5113397 | cell-based format | Scientific Literature | ||
16. | ALA5115068 | F | Antiviral activity against SARS-CoV-2 Wuhan-HU-1 infected African green monkey Vero E6 cells preincubated for 1 hrs followed by incubation with virus 1 hr and measured after 24 hrs by fluorescence assay | Severe acute respiratory syndrome coronavirus 2 | 2 | ALA5113397 | organism-based format | Scientific Literature | |
17. | ALA5115069 | T | Cytotoxicity against African green monkey Vero E6 cells assessed as inhibition of cell growth incubated for 48 hrs by MTT assay | Chlorocebus sabaeus | 2 | ALA5113397 | cell-based format | Scientific Literature | |
18. | ALA5115070 | T | Selectivity index, ratio of CC50 for cytotoxicity against African green monkey Vero E6 cells to EC50 for antiviral activity against SARS-CoV-2 Wuhan-Hu-1 infected African green monkey Vero E6 cells | 2 | ALA5113397 | cell-based format | Scientific Literature |