# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4411612 | B | Stabilization of 5'-FAM/3'-TAMRA labelled AR1 G-quadruplex oligonucleotide (unknown origin) assessed as change in melting temperature t1/2 at 1 uM after 16 hrs in presence of 100 mM K+ by FRET assay | Not specified | 9 | ALA4411261 | nucleic acid format | Scientific Literature | |
2. | ALA4411613 | B | Stabilization of 5'-FAM/3'-TAMRA labelled AR3 G-quadruplex oligonucleotide (unknown origin) assessed as change in melting temperature t1/2 at 1 uM after 16 hrs in presence of 100 mM K+ by FRET assay | Not specified | 9 | ALA4411261 | nucleic acid format | Scientific Literature | |
3. | ALA4411614 | B | Stabilization of 5'-FAM/3'-TAMRA labelled CTATAGCGCGCTATAG dsDNA (unknown origin) assessed as change in melting temperature t1/2 at 1 uM after 16 hrs in presence of 100 mM K+ by FRET assay | Not specified | 9 | ALA4411261 | assay format | Scientific Literature | |
4. | ALA4411615 | B | Binding affinity to 5'-Biotinylated-AR1 G-quadruplex oligonucleotide (unknown origin) by SPR analysis | Not specified | 9 | ALA4411261 | nucleic acid format | Scientific Literature | |
5. | ALA4411616 | B | Binding affinity to 5'-Biotinylated-AGTGAGAGTGAGAGAGAGAGTGAGAGTGAGAGTGA ssDNA (unknown origin) by SPR analysis | Not specified | 1 | ALA4411261 | assay format | Scientific Literature | |
6. | ALA4411617 | B | Binding affinity to 5'-Biotinylated-AR1 G-quadruplex oligonucleotide (unknown origin) by SPR analysis relative to control | Not specified | 9 | ALA4411261 | nucleic acid format | Scientific Literature | |
7. | ALA4411618 | A | Cytotoxicity against human PNT1A cells assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 9 | ALA4411261 | cell-based format | Scientific Literature | |
8. | ALA4411619 | F | Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 9 | ALA4411261 | cell-based format | Scientific Literature | |
9. | ALA4411620 | F | Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 9 | ALA4411261 | cell-based format | Scientific Literature | |
10. | ALA4411621 | F | Cytotoxicity against human LNCAP cells expressing androgen receptor T877A point mutant assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 9 | ALA4411261 | cell-based format | Scientific Literature | |
11. | ALA4411622 | F | Cytotoxicity against human 22Rv1 cells expressing full length androgen receptor H875Y point mutant assessed as reduction in cell viability after 48 hrs by MTS assay | Homo sapiens | 9 | ALA4411261 | cell-based format | Scientific Literature | |
12. | ALA4411623 | A | Drug uptake in human PNT1A cells at 160 nM after 24 hrs by DAPI staining-based fluorescence microscopic analysis | Homo sapiens | 1 | ALA4411261 | cell-based format | Scientific Literature | |
13. | ALA4411624 | A | Drug uptake in human PC3 cells at 160 nM after 24 hrs by DAPI staining-based fluorescence microscopic analysis | Homo sapiens | 1 | ALA4411261 | cell-based format | Scientific Literature | |
14. | ALA4411625 | A | Drug uptake in human 22Rv1 cells expressing full length androgen receptor H875Y point mutant at 160 nM after 24 hrs by DAPI staining-based fluorescence microscopic analysis | Homo sapiens | 1 | ALA4411261 | cell-based format | Scientific Literature | |
15. | ALA4411626 | B | Stabilization of AR G-quadruplex oligonucleotide in human 22Rv1 cells assessed as reduction in AR-FL protein level at IC50 after 48 hrs by Western immunoblot assay | Homo sapiens | 2 | ALA4411261 | cell-based format | Scientific Literature | |
16. | ALA4411627 | B | Stabilization of AR G-quadruplex oligonucleotide in human 22Rv1 cells assessed as reduction in AR-VS protein level at IC50 after 48 hrs by Western immunoblot assay | Homo sapiens | 2 | ALA4411261 | cell-based format | Scientific Literature | |
17. | ALA4411632 | B | Stabilization of AR G-quadruplex oligonucleotide in human 22Rv1 cells assessed as reduction in AR mRNA expression at IC50 after 6 to 72 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4411261 | cell-based format | Scientific Literature | |
18. | ALA4411633 | B | Stabilization of AR G-quadruplex oligonucleotide in human LNCAP cells assessed as reduction in AR-FL protein level by immunoblotting assay | Homo sapiens | 2 | ALA4411261 | cell-based format | Scientific Literature | |
19. | ALA4411634 | B | Stabilization of AR G-quadruplex oligonucleotide in human 22Rv1 cells assessed as down-regulation of KLK3 mRNA expression at IC50 after 6 to 72 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4411261 | cell-based format | Scientific Literature | |
20. | ALA4411635 | B | Stabilization of AR G-quadruplex oligonucleotide in human LNCAP cells assessed as reduction in AR mRNA expression at IC50 after 48 hrs by RT-PCR analysis | Homo sapiens | 1 | ALA4411261 | cell-based format | Scientific Literature |