| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4383192 | A | Drug metabolism in human liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | Homo sapiens | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 2. | ALA4383193 | T | Therapeutic index, ratio EC50 for human MRC5 SV2 cells to EC50 for Trypanosoma cruzi Tulahuen CL2 intracellular amastigotes | 30 | ALA4382200 | cell-based format | Scientific Literature | ||
| 3. | ALA4383194 | F | Antiparasitic activity against Trypanosoma cruzi Tulahuen CL2 intracellular amastigotes expressing beta-galactosidase infected in human MRC5 SV2 cells after 7 days by chlorophenol red beta-D-galactopyranoside-based spectrophotometric analysis | Trypanosoma cruzi | 30 | ALA4382200 | organism-based format | Scientific Literature | |
| 4. | ALA4383195 | A | Cytotoxicity against human MRC5 SV2 cells assessed as reduction in cell viability after 3 days resazurin-based fluorimetric assay | Homo sapiens | 30 | ALA4382200 | cell-based format | Scientific Literature | |
| 5. | ALA4383196 | A | Drug metabolism in mouse liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | Mus musculus | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 6. | ALA4383197 | A | Drug metabolism in mouse liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | Mus musculus | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 7. | ALA4383198 | A | Drug metabolism in mouse liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | Mus musculus | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 8. | ALA4383199 | A | Drug metabolism in mouse liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 15 mins by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 9. | ALA4383200 | A | Drug metabolism in mouse liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 30 mins by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 10. | ALA4383201 | A | Drug metabolism in mouse liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 60 mins by UPLC-MS/MS analysis | Mus musculus | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 11. | ALA4383202 | A | Drug metabolism in rat liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | Rattus norvegicus | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 12. | ALA4383203 | A | Drug metabolism in rat liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | Rattus norvegicus | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 13. | ALA4383204 | A | Drug metabolism in rat liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | Rattus norvegicus | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 14. | ALA4383205 | A | Drug metabolism in rat liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 15 mins by UPLC-MS/MS analysis | Rattus norvegicus | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 15. | ALA4383206 | A | Drug metabolism in rat liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 30 mins by UPLC-MS/MS analysis | Rattus norvegicus | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 16. | ALA4383207 | A | Drug metabolism in rat liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 60 mins by UPLC-MS/MS analysis | Rattus norvegicus | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 17. | ALA4383208 | A | Drug metabolism in dog liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 15 mins by UPLC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 18. | ALA4383209 | A | Drug metabolism in dog liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 30 mins by UPLC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4382200 | microsome format | Scientific Literature | |
| 19. | ALA4383210 | A | Drug metabolism in dog liver microsome S9 fraction assessed as UGT-mediated metabolism by measuring compound remaining at 5 uM pretreated with UDPGA and measured after 30 mins by UPLC-MS/MS analysis | Canis lupus familiaris | 3 | ALA4382200 | microsome format | Scientific Literature | |
| 20. | ALA4383211 | A | Drug metabolism in dog liver microsome S9 fraction assessed as CYP450-mediated metabolism by measuring compound remaining at 5 uM pretreated with NADPH and measured after 60 mins by UPLC-MS/MS analysis | Canis lupus familiaris | 4 | ALA4382200 | microsome format | Scientific Literature |
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