# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4351126 | B | Inhibition of PI3Kdelta in human SUDHL6 cells | Homo sapiens | 1 | ALA4350952 | cell-based format | Scientific Literature | |
2. | ALA4351127 | B | Inhibition of PI3Kgamma in human SUDHL6 cells | Homo sapiens | 1 | ALA4350952 | cell-based format | Scientific Literature | |
3. | ALA4351128 | B | Selectivity ratio of IC50 for PI3Kalpha in human SUDHL6 cells to IC50 for PI3Kdelta in human SUDHL6 cells | Homo sapiens | 1 | ALA4350952 | cell-based format | Scientific Literature | |
4. | ALA4351129 | B | Selectivity ratio of IC50 for PI3Kbeta in human SUDHL6 cells to IC50 for PI3Kdelta in human SUDHL6 cells | Homo sapiens | 1 | ALA4350952 | cell-based format | Scientific Literature | |
5. | ALA4351130 | F | Cytotoxicity against in human SUDHL6 cells | Homo sapiens | 1 | ALA4350952 | cell-based format | Scientific Literature | |
6. | ALA4385716 | B | Selectivity ratio of IC50 for His-tagged recombinant human full length PI3K p110alpha/p85alpha to IC50 for His-tagged recombinant human PI3K p110delta/p85alpha | Homo sapiens | 5 | ALA4385593 | assay format | Scientific Literature | |
7. | ALA4385717 | B | Inhibition of His6-tagged recombinant full length human N-terminal PI3Kbeta expressed in baculovirus infected Sf21 cells using lipid substrate incubated for 2 hrs by ADP-Glo assay | Homo sapiens | 5 | ALA4385593 | cell-based format | Scientific Literature | |
8. | ALA4385718 | B | Inhibition of His-tagged recombinant human PI3K p110delta/p85alpha using lipid substrate incubated for 2 hrs by ADP-Glo assay | Homo sapiens | 30 | ALA4385593 | protein complex format | Scientific Literature | |
9. | ALA4385719 | F | Growth inhibition of human SU-DHL6 cells incubated for 72 hrs by CellTiter-Glo assay | Homo sapiens | 16 | ALA4385593 | cell-based format | Scientific Literature | |
10. | ALA4385720 | B | Inhibition of His-tagged recombinant human full length PI3K p110alpha/p85alpha expressed in baculovirus expression system using lipid substrate incubated for 60 mins by kinase-Glo reagent based luminescence assay | Homo sapiens | 5 | ALA4385593 | assay format | Scientific Literature | |
11. | ALA4385721 | B | Inhibition of His-tagged recombinant human full length PI3K p110gamma expressed in baculovirus expression system using lipid substrate incubated for 2 hrs by ADP-Glo assay | Homo sapiens | 5 | ALA4385593 | assay format | Scientific Literature | |
12. | ALA4385722 | B | Selectivity ratio of IC50 for His6-tagged recombinant full length human N-terminal PI3Kbeta to IC50 for His-tagged recombinant human PI3K p110delta/p85alpha | Homo sapiens | 5 | ALA4385593 | assay format | Scientific Literature | |
13. | ALA4385723 | B | Selectivity ratio of IC50 for His-tagged recombinant human full length PI3K p110gamma to IC50 for His-tagged recombinant human PI3K p110delta/p85alpha | Homo sapiens | 5 | ALA4385593 | assay format | Scientific Literature | |
14. | ALA4385724 | A | Half life in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature | |
15. | ALA4385725 | A | AUC (0 to t) in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature | |
16. | ALA4385726 | A | Volume of distribution at steady state in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature | |
17. | ALA4385727 | A | Clearance in Sprague-Dawley rat at 2 mg/kg, iv by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature | |
18. | ALA4385728 | A | Cmax in Sprague-Dawley rat at 10 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature | |
19. | ALA4385729 | A | AUC (0 to t) in Sprague-Dawley rat at 10 mg/kg, po by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature | |
20. | ALA4385730 | A | Oral bioavailability in Sprague-Dawley rat at 10 mg/kg by LC/MS/MS analysis | Rattus norvegicus | 2 | ALA4385593 | organism-based format | Scientific Literature |