| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4397500 | F | Agonist activity at recombinant human V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 2. | ALA4397503 | B | Agonist activity at recombinant human V1B receptor expressed in HEK293 cells measured after 5 hrs by luciferase reporter gene assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 3. | ALA4397506 | B | Selectivity ratio of EC50 for recombinant human V1B receptor expressed in HEK293 cells to EC50 for recombinant human V2 receptor expressed in HEK293 cells | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 4. | ALA4397507 | A | Agonist activity at recombinant human V1a receptor expressed in HEK293 cells up to 1000 nM measured after 5 hrs by luciferase reporter gene assay | Homo sapiens | 43 | cell-based format | Scientific Literature | ||
| 5. | ALA4397508 | A | Clearance in Sprague-Dawley rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 43 | organism-based format | Scientific Literature | ||
| 6. | ALA4397509 | A | Non-renal clearance in nephrectomized Sprague-Dawley rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 43 | organism-based format | Scientific Literature | ||
| 7. | ALA4397510 | A | Protein binding in rat plasma at 200 to 1000 ng/ml measured after 15 mins by UC-LC/MS/MS analysis | Rattus norvegicus | 43 | cell-free format | Scientific Literature | ||
| 8. | ALA4397511 | B | Agonist activity at human OTR stably expressed in CHOK1 cells up to 10000 nM by NFAT-luciferase reporter gene assay | Homo sapiens | 31 | cell-based format | Scientific Literature | ||
| 9. | ALA4397512 | F | Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 10. | ALA4397513 | F | Agonist activity at recombinant rat V2 receptor expressed in HEK293 cells measured after 5 hrs by cAMP response element driven luciferase reporter gene assay relative to control | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 11. | ALA4397514 | A | Elimination half life in Sprague-Dawley rat at 0.1 mg/kg, iv administered as cassette dose by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 12. | ALA4397515 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output administered as iv infusion for 180 mins measured during compound dosing | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 13. | ALA4397516 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as effective plasma concentration causing half-maximal suppression of urine output administered as iv infusion for 180 mins measured during compound dosing | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 14. | ALA4397517 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output by measuring cumulative urine weight administered as iv infusion for 180 mins measured during compound dosing | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 15. | ALA4397519 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output by measuring cumulative urine weight at 30 to 100 pM administered as iv infusion for 180 mins measured up to 300 mins | Rattus norvegicus | 2 | organism-based format | Scientific Literature | ||
| 16. | ALA4397520 | U | Ratio of EC50 for agonist activity at recombinant rat V2 receptor expressed in HEK293 cells to EC50 for antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as effective plasma concentration causing half-maximal suppression of urine output | 3 | cell-based format | Scientific Literature | |||
| 17. | ALA4397521 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output at MED administered as iv infusion for 180 mins measured during compound dosing relative to control | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 18. | ALA4397523 | A | Half life in iv dosed Sprague-Dawley rat by LC-MS/MS analysis | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 19. | ALA4397525 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output at 30 to 100 pM administered as iv infusion for 180 mins measured within 1 hr | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4397526 | F | Antidiuretic activity in hydrated-euvolemic Sprague-Dawley rat assessed as suppression of urine output at 30 pM administered as iv infusion for 180 mins measured immediately | Rattus norvegicus | 1 | organism-based format | Scientific Literature |
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