# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4427798 | B | Inhibition of human CENP-E motor domain assessed as ADP levels preincubated with protein motor domain/microtubule for 60 mins followed by ATP addition measured after 20 mins by ADPglo assay | Homo sapiens | 8 | ALA4425180 | single protein format | Scientific Literature | |
2. | ALA4427799 | F | Growth inhibition in human HeLa cells assessed as cellular ATP levels after 3 days by CellTiterGlo assay | Homo sapiens | 8 | ALA4425180 | cell-based format | Scientific Literature | |
3. | ALA4427800 | B | Inhibition of CENP-E in human HeLa cells assessed as HH3 phosphorylated levels after 24 hrs by FACS analysis | Homo sapiens | 2 | ALA4425180 | cell-based format | Scientific Literature | |
4. | ALA4427801 | A | Drug uptake in tumor of human Colo205 cells xenografted in nude mouse at 100 mg/kg, ip administered qd after 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4425180 | organism-based format | Scientific Literature | |
5. | ALA4427802 | A | Plasma concentration in human Colo205 cells xenografted in nude mouse at 100 mg/kg, ip qd after 24 hrs by LC-MS/MS analysis | Mus musculus | 2 | ALA4425180 | organism-based format | Scientific Literature | |
6. | ALA4427803 | F | In vivo inhibition of CENP-E in human Colo205 cells xenografted in nude mouse assessed as phosphorylated HH3 accumulation levels in tumor measured by band intensity at 100 mg/kg, ip administered qd after 24 hrs by Western blot analysis relative to control | Mus musculus | 2 | ALA4425180 | organism-based format | Scientific Literature |