# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4348113 | Functional | Induction of membrane disruption in human MCF7/PTX cells incubated for 12 hrs by LDH release assay | Homo sapiens | 4 | ALA4346678 | cell-based format | Scientific Literature | |
2. | ALA4348124 | Functional | Induction of apoptosis in human MCF7/PTX cells assessed as late apoptotic cells at 3 uM incubated for 12 hrs by Annexin V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 0.9%) | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
3. | ALA4348126 | Functional | Cytotoxicity against human MCF7 cells incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
4. | ALA4348127 | Functional | Cytotoxicity against human MCF7/PTX cells incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
5. | ALA4348128 | Functional | Cytotoxicity against human K562 cells incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
6. | ALA4348129 | Functional | Cytotoxicity against human A2780 cells incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
7. | ALA4348130 | Functional | Cytotoxicity against human SKOV3 cells incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
8. | ALA4348132 | ADME | Cytotoxicity against HUVEC incubated for 48 hrs by MTT assay | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
9. | ALA4348136 | Functional | Induction of apoptosis in human MCF7/PTX cells assessed as necrotic cells at 3 uM incubated for 12 hrs by Annexin V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 2.1%) | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
10. | ALA4348137 | Functional | Induction of apoptosis in human MCF7/PTX cells assessed as live cells at 3 uM incubated for 12 hrs by Annexin V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 95.9%) | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
11. | ALA4348138 | Functional | Induction of apoptosis in human MCF7/PTX cells assessed as early apoptotic cells at 3 uM incubated for 12 hrs by Annexin V-FITC/propidium iodide staining based flow cytometric analysis (Rvb = 1.1%) | Homo sapiens | 7 | ALA4346678 | cell-based format | Scientific Literature | |
12. | ALA4348139 | ADME | Hemolytic activity in Wistar rat erythrocytes incubated for 1 hr | Rattus norvegicus | 4 | ALA4346678 | cell-based format | Scientific Literature | |
13. | ALA4348140 | ADME | Drug uptake in human MCF7/PTX cells at 1 to 6 uM incubated for 2 hrs using FITC-labelled compound by flow cytometric analysis | Homo sapiens | 2 | ALA4346678 | cell-based format | Scientific Literature | |
14. | ALA4348141 | Functional | Cytotoxicity against human MCF7/PTX cells at 1 to 6 uM incubated for 48 hrs by MTT assay | Homo sapiens | 2 | ALA4346678 | cell-based format | Scientific Literature | |
15. | ALA4348142 | Functional | Cytotoxicity against human MCF7 cells at 1 to 6 uM incubated for 48 hrs by MTT assay | Homo sapiens | 1 | ALA4346678 | cell-based format | Scientific Literature | |
16. | ALA4348143 | Functional | Induction of membrane disruption in human MCF7/PTX cells at 3 uM incubated for 12 hrs by AO/EB double staining based fluorescence microscopic method | Homo sapiens | 4 | ALA4346678 | cell-based format | Scientific Literature | |
17. | ALA4348150 | Functional | Induction of mitochondrial membrane potential loss in human MCF7/PTX cells at 3 uM incubated for 12 hrs by JC1 staining-based confocal microscopic method | Homo sapiens | 2 | ALA4346678 | cell-based format | Scientific Literature | |
18. | ALA4348151 | Functional | Induction of apoptosis in human MCF7/PTX cells assessed as increase in cleaved caspase 3 level in cytoplasm at 3 uM incubated for 2 hrs by Western blot analysis | Homo sapiens | 2 | ALA4346678 | cell-based format | Scientific Literature | |
19. | ALA4348152 | Functional | Induction of apoptosis in human MCF7/PTX cells assessed increase in cytochrome-c expression in cytoplasm at 3 uM incubated for 2 hrs by Western blot analysis | Homo sapiens | 2 | ALA4346678 | cell-based format | Scientific Literature | |
20. | ALA4348162 | Functional | Induction of membrane disruption in human MCF7/PTX cells incubated for 12 hrs by AO/EB double-staining based fluorescence microscopic method | Homo sapiens | 2 | ALA4346678 | cell-based format | Scientific Literature |