| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4428883 | B | Inhibition of human Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay | Homo sapiens | 37 | ALA4428053 | cell-based format | Scientific Literature | |
| 2. | ALA4428884 | B | Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 3 to 5 mins at -50 mV holding potential by electrophysiology assay | Homo sapiens | 37 | ALA4428053 | cell-based format | Scientific Literature | |
| 3. | ALA4428885 | B | Displacement of [3H]dofetilide from human ERG expressed in HEK293 cells after 45 mins by scintillation counting analysis | Homo sapiens | 10 | ALA4428053 | cell-based format | Scientific Literature | |
| 4. | ALA4428886 | A | Intrinsic clearance in human liver microsomes at 1 uM after 1 to 40 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 30 | ALA4428053 | microsome format | Scientific Literature | |
| 5. | ALA4428887 | A | Intrinsic clearance in rat liver microsomes at 1 uM after 1 to 40 mins in presence of NADPH by LC-MS/MS analysis | Rattus norvegicus | 30 | ALA4428053 | microsome format | Scientific Literature | |
| 6. | ALA4428888 | P | Equilibrium solubility of the compound in PBS at 1 mg at pH 7.4 after 24 hrs by HPLC based shake flask method | 2 | ALA4428053 | small-molecule physicochemical format | Scientific Literature | ||
| 7. | ALA4428889 | P | Equilibrium solubility of the compound in fasted state simulated intestinal fluid at 1 mg at pH 6.8 after 24 hrs by HPLC based shake flask method | 2 | ALA4428053 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4428891 | A | Inhibition of CYP3A4 in human microsomes using midazolam as substrate coincubated with substrate for 30 mins measured after 5 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | ALA4428053 | microsome format | Scientific Literature | |
| 9. | ALA4428892 | A | Inhibition of CYP2D6 in human microsomes using dextromethorphan as substrate coincubated with substrate for 30 mins measured after 5 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | ALA4428053 | microsome format | Scientific Literature | |
| 10. | ALA4428893 | A | Inhibition of CYP2C9 in human microsomes using diclofenac as substrate coincubated with substrate for 30 mins measured after 5 mins in presence of NADPH by LC-MS/MS analysis | Homo sapiens | 3 | ALA4428053 | microsome format | Scientific Literature | |
| 11. | ALA4428894 | A | Inhibition of CYP3A4 in human microsomes using midazolam as substrate preincubated with enzyme and NADPH prior to substrate addition by LC-MS/MS analysis | Homo sapiens | 3 | ALA4428053 | microsome format | Scientific Literature | |
| 12. | ALA4428895 | A | Inhibition of CYP2D6 in human microsomes using dextromethorphan as substrate incubated with enzyme and NADPH prior to substrate addition by LC-MS/MS analysis | Homo sapiens | 3 | ALA4428053 | microsome format | Scientific Literature | |
| 13. | ALA4428896 | A | Inhibition of CYP2C9 in human microsomes using diclofenac as substrate incubated with enzyme and NADPH prior to substrate addition by LC-MS/MS analysis | Homo sapiens | 3 | ALA4428053 | microsome format | Scientific Literature | |
| 14. | ALA4428898 | B | Inhibition of rat Nav1.7 expressed in HEK293T cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay | Rattus norvegicus | 1 | ALA4428053 | cell-based format | Scientific Literature | |
| 15. | ALA4428899 | B | Inhibition of mouse Nav1.7 expressed in HEK293 cells incubated for 3 to 5 mins at -125 mV holding potential by electrophysiology assay | Mus musculus | 1 | ALA4428053 | cell-based format | Scientific Literature | |
| 16. | ALA4428900 | A | AUC (infinity) in Harlan rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4428053 | organism-based format | Scientific Literature | |
| 17. | ALA4428901 | A | AUC (infinity) in Harlan rat at 10 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4428053 | organism-based format | Scientific Literature | |
| 18. | ALA4428902 | A | Clearance in Harlan rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4428053 | organism-based format | Scientific Literature | |
| 19. | ALA4428903 | A | Half life in Harlan rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4428053 | organism-based format | Scientific Literature | |
| 20. | ALA4428904 | A | Volume of distribution in Harlan rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4428053 | organism-based format | Scientific Literature |
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