| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4428708 | B | Inhibition of polyHis tagged full length recombinant PI3Kdelta (unknown origin) expressed in Sf9 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 2. | ALA4428709 | B | Inhibition of polyHis tagged full length recombinant PI3Kalpha (unknown origin) expressed in Sf9 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 3. | ALA4428710 | B | Inhibition of polyHis tagged full length recombinant PI3Kbeta (unknown origin) expressed in Sf9 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 4. | ALA4428711 | B | Inhibition of N-terminal polyHis tagged full length recombinant PI3Kgamma (114 to 1102 residues) (unknown origin) expressed in Hi5 cells co-expressing p85 incubated for 20 mins by alpha screen assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 5. | ALA4428712 | F | Inhibition of cell proliferation of human B cells pre-incubated for 30 mins before anti-IgM/CD40L stimulation and measured after 72 hrs by [3H]thymidine incorporation assay | Homo sapiens | 17 | cell-based format | Scientific Literature | ||
| 6. | ALA4428713 | B | Inhibition of PI3Kdelta in BALB/c mouse B cells assessed as reduction in Anti-IgM induced AKT Ser473 phosphorylation pre-incubated for 45 mins before Anti-IgM stimulation | Mus musculus | 17 | cell-based format | Scientific Literature | ||
| 7. | ALA4428714 | A | Clearance in rat liver microsomes assessed as drug turnover level at 1 uM incubated for 30 mins in presence of NADPH | Rattus norvegicus | 17 | microsome format | Scientific Literature | ||
| 8. | ALA4428715 | A | Clearance in human liver microsomes assessed as drug turnover level at 1 uM incubated for 30 mins in presence of NADPH | Homo sapiens | 17 | microsome format | Scientific Literature | ||
| 9. | ALA4428716 | A | Inhibition of CYP3A4 (unknown origin) at 3 uM using midazolam substrate by LC-MS method | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 10. | ALA4428717 | A | Inhibition of CYP2D6 (unknown origin) at 3 uM using midazolam substrate by LC-MS method | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 11. | ALA4428718 | A | Activation of human PXR assessed as remaining activity at 2 uM relative to untreated control | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 12. | ALA4428719 | A | Activation of human PXR assessed as remaining activity at 10 uM relative to untreated control | Homo sapiens | 17 | single protein format | Scientific Literature | ||
| 13. | ALA4428720 | A | Clearance in Sprague-Dawley rat at 0.5 mg/kg, iv by by LC-MS method | Rattus norvegicus | 17 | organism-based format | Scientific Literature | ||
| 14. | ALA4428721 | A | Unbound clearance in Sprague-Dawley rat at 0.5 mg/kg, iv by by LC-MS method | Rattus norvegicus | 17 | organism-based format | Scientific Literature | ||
| 15. | ALA4428722 | B | Selectivity index, ratio of IC50 for inhibition of polyHis tagged full length recombinant PI3Kalpha (unknown origin) expressed in Sf9 cells co-expressing p85 to IC50 for polyHis tagged full length recombinant PI3Kdelta (unknown origin) expressed in Sf9 cells co-expressing p85 | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA4428723 | B | Selectivity index, ratio of IC50 for inhibition of polyHis tagged full length recombinant PI3Kbeta (unknown origin) expressed in Sf9 cells co-expressing p85 to IC50 for polyHis tagged full length recombinant PI3Kdelta (unknown origin) expressed in Sf9 cells co-expressing p85 | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA4428724 | B | Selectivity index, ratio of IC50 for inhibition of N-terminal polyHis tagged full length recombinant PI3Kgamma (114 to 1102 residues) (unknown origin) expressed in Hi5 cells co-expressing p85 o IC50 for polyHis tagged full length recombinant PI3Kdelta (unknown origin) expressed in Sf9 cells co-expressing p85 | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 18. | ALA4428725 | B | Inhibition of PI3Kdelta in human whole blood assessed as inhibition of Anti-IgD antibody-induced AKT Ser473 phosphorylation pre-incubated for 60 mins before Anti-IgD antibody stimulation | Homo sapiens | 3 | tissue-based format | Scientific Literature | ||
| 19. | ALA4428726 | P | Aqueous equilibrium solubility at room temperature after 72 hrs at pH 7.4 by HPLC | 3 | small-molecule physicochemical format | Scientific Literature | |||
| 20. | ALA4428727 | A | Apparent permeability in LLC-PK1 cells by LC-MS method | Sus scrofa | 3 | cell-based format | Scientific Literature |
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