| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4396692 | B | Agonist activity at full length human FLAG-tagged GAL4-DBD fused RXRalpha LBD (202 to 462 residues) expressed in COS1 cells at 25 to 50 uM measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 2. | ALA4396693 | B | Agonist activity at PPARalpha in C57BL/6N mouse primary hepatocytes assessed as activation of Cpt1a mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Mus musculus | 2 | ALA4393735 | cell-based format | Scientific Literature | |
| 3. | ALA4396696 | A | Cytotoxicity against African green monkey COS1 cells assessed as reduction in cell viability at 10'-4 M by LDH release assay | Chlorocebus aethiops | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 4. | ALA4396697 | A | Cytotoxicity against African green monkey COS1 cells assessed as reduction in cell viability at 10'-4 M by XTT based assay | Chlorocebus aethiops | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 5. | ALA4396698 | A | Cytotoxicity against African green monkey COS1 cells assessed as reduction in cell viability at 10'-3 M by LDH release assay relative to control | Chlorocebus aethiops | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 6. | ALA4396699 | A | Cytotoxicity against African green monkey COS1 cells assessed as reduction in cell viability at 10'-3 M by XTT based assay relative to control | Chlorocebus aethiops | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 7. | ALA4396700 | B | Agonist activity at full length human FLAG-tagged GAL4-DBD fused PPARalpha LBD (168 to 468 residues) expressed in COS1 cells measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 8. | ALA4396701 | B | Agonist activity at full length human FLAG-tagged GAL4-DBD fused PPARgamma LBD (205 to 505 residues) expressed in COS1 cells measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 9. | ALA4396704 | B | Agonist activity at full length human FLAG-tagged GAL4-DBD fused PPARalpha LBD (168 to 468 residues) expressed in COS1 cells at 25 to 50 uM measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 10. | ALA4396705 | B | Agonist activity at full length human GAL4-DBD fused PPARdelta LBD expressed in COS1 cells at 25 to 50 uM measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 11. | ALA4396706 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as PPARA mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
| 12. | ALA4396707 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as activation of CPT1A mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 2 | ALA4393735 | cell-based format | Scientific Literature | |
| 13. | ALA4396708 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as SCD1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
| 14. | ALA4396709 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as SREBF1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
| 15. | ALA4396712 | B | Agonist activity at PPARalpha in C57BL/6N mouse primary hepatocytes assessed as SCD1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Mus musculus | 4 | ALA4393735 | cell-based format | Scientific Literature | |
| 16. | ALA4396713 | B | Agonist activity at PPARalpha in C57BL/6N mouse primary hepatocytes assessed as SREBF1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Mus musculus | 4 | ALA4393735 | cell-based format | Scientific Literature | |
| 17. | ALA4396714 | B | Agonist activity at full length human FLAG-taggedGAL4-DBD fused PPARgamma LBD (205 to 505 residues) expressed in COS1 cells at 25 to 50 uM measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 18. | ALA4396715 | B | Agonist activity at full length human GAL4-DBD fused LXRalpha LBD (164 to 447 residues) expressed in COS1 cells at 25 to 50 uM measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 19. | ALA4396716 | B | Agonist activity at full length human GAL4-DBD fused LXRbeta LBD (155 to 461 residues) expressed in COS1 cells at 25 to 50 uM measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature | |
| 20. | ALA4396717 | B | Inverse agonist activity at full length human FLAG-tagged GAL4-DBD fused PPARgamma LBD (205 to 505 residues) expressed in COS1 cells assessed as inhibition of rosiglitazone binding measured after 18 hrs by dual luciferase reporter gene assay | Homo sapiens | 1 | ALA4393735 | cell-based format | Scientific Literature |
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