# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4348478 | Binding | Inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 9 | ALA4346688 | assay format | Scientific Literature | |
2. | ALA4348479 | Binding | Inhibition of FGFR (unknown origin) incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | protein format | Scientific Literature | |
3. | ALA4348480 | Binding | Inhibition of N-terminal GST-tagged human EGFR cytoplasmic domain (669 to 1210 residues) expressed in Baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 9 | ALA4346688 | assay format | Scientific Literature | |
4. | ALA4348481 | ADME | AUCt in Sprague-Dawley rat at 10 mg/kg, po by UPLC/MS/MS analysis | Rattus norvegicus | 3 | ALA4346688 | organism-based format | Scientific Literature | |
5. | ALA4348482 | Binding | Potency index, ratio of IC50 for ceritinib to IC50 for test compound for inhibition of N-terminal GST-tagged human ROS1 cytoplasmic domain (1883 to 2347 residues) expressed in Baculovirus expression system using IRS1 as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | assay format | Scientific Literature | |
6. | ALA4348483 | Functional | Cytotoxicity against human KARPAS299 cells incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA4346688 | cell-based format | Scientific Literature | |
7. | ALA4348484 | Functional | Cytotoxicity against human NCI-H2228 cells incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA4346688 | cell-based format | Scientific Literature | |
8. | ALA4348485 | Functional | Cytotoxicity against mouse BA/F3 cells harboring ALK G1202R mutation incubated for 72 hrs by MTT assay | Mus musculus | 30 | ALA4346688 | cell-based format | Scientific Literature | |
9. | ALA4348486 | ADME | Cytotoxicity against mouse BA/F3 cells incubated for 72 hrs by MTT assay | Mus musculus | 30 | ALA4346688 | cell-based format | Scientific Literature | |
10. | ALA4348487 | Functional | Cytotoxicity against human HCC78 cells incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA4346688 | cell-based format | Scientific Literature | |
11. | ALA4348488 | Functional | Cytotoxicity against human A549 cells harboring ALK G1202R mutation incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA4346688 | cell-based format | Scientific Literature | |
12. | ALA4348489 | Functional | Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay | Homo sapiens | 30 | ALA4346688 | cell-based format | Scientific Literature | |
13. | ALA4348490 | Binding | Inhibition of N-terminal GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in Baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 9 | ALA4346688 | assay format | Scientific Literature | |
14. | ALA4348491 | Binding | Inhibition of N-terminal GST-tagged human ALK L1196M mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 9 | ALA4346688 | assay format | Scientific Literature | |
15. | ALA4348492 | Binding | Inhibition of N-terminal GST-tagged human ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 9 | ALA4346688 | assay format | Scientific Literature | |
16. | ALA4348493 | Binding | Potency index, ratio of IC50 for ceritinib to IC50 for test compound for inhibition of N-terminal GST-tagged human ALK G1202R mutant cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | assay format | Scientific Literature | |
17. | ALA4348494 | Binding | Inhibition of N-terminal GST-tagged human c-MET cytoplasmic domain (956 to 1390 residues) expressed in Baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | assay format | Scientific Literature | |
18. | ALA4348495 | Binding | Inhibition of PI3K (unknown origin) incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | assay format | Scientific Literature | |
19. | ALA4348496 | Binding | Inhibition of N-terminal GST-tagged full length human CDK4 (1 to 303 residues) expressed in Baculovirus expression system using DYRKtide F as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | assay format | Scientific Literature | |
20. | ALA4348497 | Binding | Inhibition of N-terminal GST-tagged human JAK2 catalytic domain (826 to 1132 residues) expressed in Baculovirus expression system using srctide as substrate incubated for 1 hr by mobility shift assay | Homo sapiens | 1 | ALA4346688 | assay format | Scientific Literature |