| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4390738 | B | Inhibition of recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as reduction in enzyme-mediated bovine insulin aggregation | Homo sapiens | 72 | ALA4390639 | assay format | Scientific Literature | |
| 2. | ALA4390740 | F | Cytotoxicity against human U87MG cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4390639 | cell-based format | Scientific Literature | |
| 3. | ALA4390741 | F | Cytotoxicity against human A172 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4390639 | cell-based format | Scientific Literature | |
| 4. | ALA4390742 | F | Cytotoxicity against human NU04 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 24 | ALA4390639 | cell-based format | Scientific Literature | |
| 5. | ALA4390746 | F | Induction of morphological changes in human A172 cells assessed as vesicle formation at 11 uM measured after 48 hrs by Giemsa-staining based microscopic analysis | Homo sapiens | 1 | ALA4390639 | cell-based format | Scientific Literature | |
| 6. | ALA4390747 | F | Induction of morphological changes in human A172 cells assessed as membrane blebbing at 11 uM measured after 48 hrs by Giemsa-staining based microscopic analysis | Homo sapiens | 1 | ALA4390639 | cell-based format | Scientific Literature | |
| 7. | ALA4390748 | F | Inhibition of colony formation in human U87MG cells measured after 24 hrs by crystal violet staining based assay | Homo sapiens | 7 | ALA4390639 | cell-based format | Scientific Literature | |
| 8. | ALA4390750 | F | Cytotoxicity against human U87MG cells assessed as inhibition of cell proliferation at | Homo sapiens | 23 | ALA4390639 | cell-based format | Scientific Literature | | |
| 9. | ALA4390751 | A | Cytotoxicity against HFF1 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
| 10. | ALA4390752 | U | Therapeutic ratio of IC50 for HFF1 cells to IC50 for human NU04 cells | Homo sapiens | 6 | ALA4390639 | assay format | Scientific Literature | |
| 11. | ALA4390753 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 8 | ALA4390639 | assay format | Scientific Literature | |
| 12. | ALA4390754 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS assessed as increase in melting temperature by ROX dye based thermal shift assay | Homo sapiens | 3 | ALA4390639 | assay format | Scientific Literature | |
| 13. | ALA4390755 | B | Binding affinity to recombinant human N-terminal His-tagged PDI H256A mutant expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 5 | ALA4390639 | assay format | Scientific Literature | |
| 14. | ALA4390756 | B | Binding affinity to recombinant human N-terminal His-tagged PDI C53S/C397S double mutant expressed in Escherichia coli BL21 (DE3) pLysS assessed as change in melting temperature at 100 uM by ROX dye based thermal shift assay | Homo sapiens | 4 | ALA4390639 | assay format | Scientific Literature | |
| 15. | ALA4390758 | B | Binding affinity to recombinant human N-terminal His-tagged PDI expressed in Escherichia coli BL21 (DE3) pLysS by isothermal titration calorimetry | Homo sapiens | 3 | ALA4390639 | assay format | Scientific Literature | |
| 16. | ALA4390760 | B | Induction of EIF2alpha phosphorylation in human U87MG cells at 20 uM measured after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
| 17. | ALA4390764 | F | Induction of endoplasmic reticulum stress in human U87MG cells assessed as increase in GRP78 expression at 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
| 18. | ALA4390765 | B | Induction of EIF2alpha phosphorylation in human A172 cells at 20 uM measured after 2 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
| 19. | ALA4390769 | F | Induction of endoplasmic reticulum stress in human A172 cells assessed as increase in GRP78 expression at 20 uM measured after 24 hrs by Western blot analysis | Homo sapiens | 6 | ALA4390639 | cell-based format | Scientific Literature | |
| 20. | ALA4390770 | F | Antimigratory activity against human A172 cells assessed as reduction in cell migration towards wound area at 10 uM measured after 24 hrs by Giemsa staining based microscopic analysis | Homo sapiens | 5 | ALA4390639 | cell-based format | Scientific Literature |
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