# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4409554 | B | Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production using L-tryptophan as substrate incubated for 24 hrs | Homo sapiens | 37 | cell-based format | Scientific Literature | ||
2. | ALA4409555 | A | Cytotoxicity against human HeLa cells assessed as survival rate at 30 uM incubated for 24 hrs by MTT assay relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
3. | ALA4409556 | B | Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine production at 30 uM using L-tryptophan as substrate incubated for 24 hrs relative to control | Homo sapiens | 36 | cell-based format | Scientific Literature | ||
4. | ALA4409558 | B | Reversal of IDO1-mediated immunosuppression in mouse CT26 co-cultured with T-cells assessed as increase in T cell proliferation measured after 48 hrs by MTT assay | Mus musculus | 3 | assay format | Scientific Literature | ||
5. | ALA4409560 | B | Reversal of IDO1-mediated immunosuppression in mouse CT26 co-cultured with T-cells assessed as ConA- stimulated differentiation of Treg cells at 0.3 uM measured after 48 hrs by FOXP3-APC based flow cytometry analysis (Rvb = 11.4 %) | Mus musculus | 3 | assay format | Scientific Literature | ||
6. | ALA4409575 | F | Effect on IDO1 expression in IFN-gamma-stimulated human HeLa cells at 3 times IDO1 IC50 for 24 hrs by western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature |