| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4409553 | B | Inhibition of IFN-gamma-induced human TDO2 transfected in HeLa cells at 10 times IDO1 IC50 concentration using L-tryptophan as substrate incubated for 24 hrs relative to control | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 2. | ALA4409557 | B | Reversal of IDO1-mediated immunosuppression in mouse CT26 co-cultured with T-cells assessed as increase in IFN-gamma production measured after 48 hrs by ELISA relative to control | Mus musculus | 1 | assay format | Scientific Literature | ||
| 3. | ALA4409558 | B | Reversal of IDO1-mediated immunosuppression in mouse CT26 co-cultured with T-cells assessed as increase in T cell proliferation measured after 48 hrs by MTT assay | Mus musculus | 3 | assay format | Scientific Literature | ||
| 4. | ALA4409560 | B | Reversal of IDO1-mediated immunosuppression in mouse CT26 co-cultured with T-cells assessed as ConA- stimulated differentiation of Treg cells at 0.3 uM measured after 48 hrs by FOXP3-APC based flow cytometry analysis (Rvb = 11.4 %) | Mus musculus | 3 | assay format | Scientific Literature | ||
| 5. | ALA4409561 | F | Antitumor activity against mouse CT26 cells xenografted in BALB/c mouse assessed as decrease in tumour growth at 50 mg/kg, po via gavage for 17 days by vernier caliper method | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 6. | ALA4409562 | F | Antitumor activity against mouse CT26 cells xenografted in BALB/c mouse assessed as decrease in tumour weight at 50 mg/kg, po via gavage for 17 days by vernier caliper method relative to control | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA4409563 | T | Toxicity in BALB/c mouse xenografted with mouse CT26 cells assessed as effect on body weight at 50 mg/kg, po via gavage for 17 days and measured at day 17 | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA4409564 | F | Antitumor activity against mouse CT26 cells xenografted in immunodeficient BALB/c nude mouse assessed as reduction in tumour growth at 50 mg/kg, po via gavage for 10 days by vernier caliper method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 9. | ALA4409566 | F | Induction of apoptosis in BALB/c mouse xenografted with CT26 cells assessed as cell shrinkage at 50 mg/kg via oral gavage for 17 days by H&E staining based analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 10. | ALA4409567 | F | Induction of apoptosis in BALB/c mouse xenografted with CT26 cells assessed as nuclear chromatin condensation at 50 mg/kg via oral gavage for 17 days by H&E staining based analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 11. | ALA4409568 | F | Induction of apoptosis in BALB/c mouse xenografted with CT26 cells assessed as nuclear chromatin margination at 50 mg/kg via oral gavage for 17 days by H&E staining based analysis | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 12. | ALA4409569 | F | Induction of apoptosis in BALB/c mouse xenografted with CT26 cells assessed as decrease in PCNA expression at 50 mg/kg via oral gavage for 17 days by immunohistochemistry analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4409570 | F | Induction of apoptosis in BALB/c mouse xenografted with CT26 cells at 50 mg/kg via oral gavage for 17 days by TUNEL assay | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4409571 | F | Increase in infiltrating CD8-positive T cells in BALB/c mouse xenografted with CT26 cells at 50 mg/kg via oral gavage for 17 day by immunohistochemical analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4409572 | F | Increase in IFN-gamma expression in BALB/c mouse xenografted with CT26 cells at 50 mg/kg via oral gavage for 17 day by immunohistochemical analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 16. | ALA4409573 | F | Decrease in FOXP3-postive T cells in BALB/c mouse xenografted with CT26 cells at 50 mg/kg via oral gavage for 17 day by immunohistochemical analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4409574 | F | Increase in Granzyme B expression in BALB/c mouse xenografted with CT26 cells at 50 mg/kg via oral gavage for 17 day by immunohistochemical analysis | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 18. | ALA4409575 | F | Effect on IDO1 expression in IFN-gamma-stimulated human HeLa cells at 3 times IDO1 IC50 for 24 hrs by western blot analysis | Homo sapiens | 5 | cell-based format | Scientific Literature |
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