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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4326431 Binding Inhibition of full length human p110alpha/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assay Homo sapiens 2 ALA4325835 protein complex format Scientific Literature 2. ALA4326432 Binding Inhibition of full length human His-tagged p110beta/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assay Homo sapiens 2 ALA4325835 protein complex format Scientific Literature 3. ALA4326433 Binding Inhibition of full length human p110delta/p85alpha using PIP2 as substrate after 30 mins by TR-FRET assay Homo sapiens 2 ALA4325835 protein complex format Scientific Literature 4. ALA4326434 Binding Inhibition of full length human PI3Kgamma using PIP2 as substrate after 30 mins by TR-FRET assay Homo sapiens 2 ALA4325835 single protein format Scientific Literature 5. ALA4326435 ADME Intrinsic clearance in human hepatocytes at 0.5 uM measured up to 250 mins by UHPLC-HRMS based assay Homo sapiens 1 ALA4325835 cell-based format Scientific Literature 6. ALA4326436 ADME Intrinsic clearance in human liver microsomes at 1 uM measured in presence of NADPH/UDPGA by UHPLC-HRMS based assay Homo sapiens 1 ALA4325835 microsome format Scientific Literature 7. ALA4326437 ADME Drug metabolism in human hepatocytes assessed as AO-mediated fraction metabolized by measuring half life with and without hydralazine at 0.5 uM measured up to 250 mins by UHPLC-HRMS based assay Homo sapiens 1 ALA4325835 cell-based format Scientific Literature 8. ALA4326438 ADME Drug metabolism in human hepatocytes assessed as AO-mediated 4-(6-(2-amino-3-fluoropyridin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzo[d]imidazol-1-yl)-5,8-difluoroquinolin-2(1H)-one metabolite formation at 0.5 uM measured up to 250 mins by UHPLC-HRMS based assay Homo sapiens 1 ALA4325835 cell-based format Scientific Literature 9. ALA4326439 ADME Drug metabolism in human hepatocytes assessed as AO-mediated triazole oxidation at 0.5 uM measured up to 250 mins by UHPLC-HRMS based assay Homo sapiens 1 ALA4325835 cell-based format Scientific Literature 10. ALA4326441 ADME Drug metabolism in human liver cytosol assessed as AO-mediated 4-(6-(2-amino-3-fluoropyridin-4-yl)-2-methyl-4-(4H-1,2,4-triazol-3-yl)-1H-benzo[d]imidazol-1-yl)-5,8-difluoroquinolin-2(1H)-one metabolite formation at 0.5 uM measured after 2 hrs by UHPLC-HRMS based assay Homo sapiens 1 ALA4325835 subcellular format Scientific Literature 11. ALA4326442 Binding Inhibition of human ERG at 25 uM Homo sapiens 1 ALA4325835 single protein format Scientific Literature 12. ALA4326443 ADME Inhibition of human CYP450 at 25 uM Homo sapiens 1 ALA4325835 protein format Scientific Literature 13. ALA4326444 ADME Fraction unbound in Sprague-Dawley rat plasma Rattus norvegicus 1 ALA4325835 cell-free format Scientific Literature 14. ALA4326445 ADME Clearance in Sprague-Dawley rat at 1 mg/kg, iv by ESI-LC/MS/MS analysis Rattus norvegicus 1 ALA4325835 organism-based format Scientific Literature 15. ALA4326446 ADME Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv by ESI-LC/MS/MS analysis Rattus norvegicus 1 ALA4325835 organism-based format Scientific Literature 16. ALA4326447 ADME Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv by ESI-LC/MS/MS analysis Rattus norvegicus 1 ALA4325835 organism-based format Scientific Literature 17. ALA4326448 ADME MRT in Sprague-Dawley rat at 1 mg/kg, iv by ESI-LC/MS/MS analysis Rattus norvegicus 1 ALA4325835 organism-based format Scientific Literature 18. ALA4326449 ADME Oral bioavailability in Sprague-Dawley rat at 5 mg/kg by ESI-LC/MS/MS analysis Rattus norvegicus 1 ALA4325835 organism-based format Scientific Literature 19. ALA4326450 ADME Fraction unbound in Beagle dog plasma Canis lupus familiaris 1 ALA4325835 cell-free format Scientific Literature 20. ALA4326451 ADME Clearance in Beagle dog at 1 mg/kg, iv by ESI-LC/MS/MS analysis Canis lupus familiaris 1 ALA4325835 organism-based format Scientific Literature