| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4342607 | B | Inhibition of C-terminal His6-tagged human BACE1 expressed in mammalian expression system preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRET assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 2. | ALA4342608 | A | Inhibition of C-terminal His6-tagged human BACE2 expressed in mammalian expression system preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRET assay | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 3. | ALA4342626 | B | Inhibition of recombinant Cathepsin D (unknown origin) expressed in CHO cells preincubated for 1 hr followed by substrate addition and measured after 1 hr by FRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 4. | ALA4342632 | F | In vivo inhibition of BACE1 in Sprague Dawley rat assessed as reduction in amyloidbeta 40 level in CSF at 10 mg/kg, po measured at 4 hrs post dose by sandwich ELISA relative to control | Rattus norvegicus | 3 | organism-based format | Scientific Literature | ||
| 5. | ALA4342637 | B | Inhibition of BACE1 (unknown origin) assessed as reduction in amyloidbeta 40 level after 24 hrs by HTRF assay | Homo sapiens | 2 | single protein format | Scientific Literature |
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