| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4404696 | A | Stability in rat liver microsomes assessed as half life at 0.5 uM | Rattus norvegicus | 1 | ALA4402573 | microsome format | Scientific Literature | |
| 2. | ALA4404697 | B | Inhibition of human ERG expressed in CHO cells by automated patch clamp electrophysiology | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 3. | ALA4404698 | A | Cmax in Sprague-Dawley rat at 2.5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4402573 | organism-based format | Scientific Literature | |
| 4. | ALA4404699 | F | Anti-VaD activity against UCCAO-induced spatial memory deficient C57BL/6J mouse model assessed as improvement in spatial learning and memory by measuring increase in frequency of platform area crossings at 10 mg/kg, po administered for 21 days by Morris water maze test | Mus musculus | 1 | ALA4402573 | organism-based format | Scientific Literature | |
| 5. | ALA4404700 | F | Anti-VaD activity against UCCAO-induced spatial memory deficient C57BL/6J mouse model assessed as improvement in spatial learning and memory by measuring reduction in escape latency at 10 mg/kg, po administered for 21 days by Morris water maze test | Mus musculus | 1 | ALA4402573 | organism-based format | Scientific Literature | |
| 6. | ALA4404701 | A | Half life in Sprague-Dawley rat at 2.5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4402573 | organism-based format | Scientific Literature | |
| 7. | ALA4404702 | A | Tmax in Sprague-Dawley rat at 2.5 mg/kg, iv measured upto 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4402573 | organism-based format | Scientific Literature | |
| 8. | ALA4404703 | B | Inhibition of human PDE4B2 (152 to 487 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 9. | ALA4404704 | B | Inhibition of human PDE4D2 (86 to 413 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 27 | ALA4402573 | cell-based format | Scientific Literature | |
| 10. | ALA4404707 | B | Inhibition of human PDE4B1 (1 to 736 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 11. | ALA4404708 | B | Inhibition of human PDE4D7 (1 to 748 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 12. | ALA4404709 | B | Inhibition of human PDE1B (10 to 487 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 13. | ALA4404710 | B | Inhibition of human PDE2A (580 to 919 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cGMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 14. | ALA4404711 | B | Inhibition of human PDE3A (679 to 1087 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 15. | ALA4404712 | B | Inhibition of human PDE5A1 (535 to 860 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cGMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 16. | ALA4404713 | B | Inhibition of human PDE7A1 (130 to 482 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 17. | ALA4404714 | B | Inhibition of human PDE8A1 (480 to 820 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 18. | ALA4404715 | B | Inhibition of human PDE9A2 (181 to 506 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cGMP as substrate incubated for 15 mins by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 19. | ALA4404716 | B | Inhibition of human PDE10A2 (449 to 770 residues) expressed in Escherichia coli BL21 codon-plus cells using [3H]cAMP as substrate incubated for 15 mins followed by substrate addition by liquid scintillation counting method | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature | |
| 20. | ALA4404717 | B | Selectivity index, ratio of IC50 for human PDE1B (10 to 487 residues) expressed in Escherichia coli BL21 codon-plus cells to IC50 for human PDE4D2 (86 to 413 residues) expressed in Escherichia coli BL21 codon-plus cells | Homo sapiens | 1 | ALA4402573 | cell-based format | Scientific Literature |
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