# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4410388 | B | Inhibition of Kv7.2/7.3 in human tsA201 cells assessed as effect on channel currents at -60 mV holding potential at 1.5 uM by whole cell patch clamp assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
2. | ALA4410389 | B | Inhibition of Kv7.2 in human HEK293 cells incubated for 1 hr by thallium flux assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
3. | ALA4410390 | B | Inhibition of ERG in human HEK293 cells incubated for 1 hr by thallium flux assay | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
4. | ALA4410391 | A | Inhibition of CYP3A4 (unknown origin) at 50 uM using DBOMF as substrate measured for each min for 6 mins by fluorescence based assay relative to control | Homo sapiens | 7 | single protein format | Scientific Literature | ||
5. | ALA4410392 | A | Metabolic stability in human liver microsomes assessed as percent remaining at 1 mM incubated for 1 hr by LC/MS analysis | Homo sapiens | 4 | microsome format | Scientific Literature | ||
6. | ALA4410393 | P | Stability in 1:1 MeCN:0.2N aq. HCl assessed as percent remaining at 0.3 mM and 60 degC incubated for 24 hrs by LC/MS analysis | 4 | small-molecule physicochemical format | Scientific Literature | |||
7. | ALA4410394 | P | Kinetic solubility in 2.5 % DMSO/water at 3.2 uM to 100 uM incubated for 18 hrs by spectrometry | 4 | small-molecule physicochemical format | Scientific Literature | |||
8. | ALA4410395 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 18 hrs by celltiter-glo assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
9. | ALA4410396 | A | Cytotoxicity against human HEK293 cells assessed as reduction in cell viability incubated for 18 hrs by celltiter-glo assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
10. | ALA4410398 | B | Inhibition of alpha1 adrenergic receptor (unknown origin) | Homo sapiens | 4 | protein format | Scientific Literature | ||
11. | ALA4410399 | B | Inhibition of PBR receptor (unknown origin) | Homo sapiens | 2 | single protein format | Scientific Literature | ||
12. | ALA4410402 | B | Binding affinity to alpha1 adrenergic receptor (unknown origin) at 10 uM relative to control | Homo sapiens | 3 | protein format | Scientific Literature | ||
13. | ALA4410403 | B | Binding affinity to PBR receptor (unknown origin) at 10 uM relative to control | Homo sapiens | 1 | single protein format | Scientific Literature | ||
14. | ALA4410405 | A | Inhibition of CYP3A4 (unknown origin) at 10 uM using DBOMF as substrate measured for each min for 6 mins by fluorescence based assay relative to control | Homo sapiens | 4 | single protein format | Scientific Literature |