# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385274 | P | Dissociation constant, pKa of the compound | 1 | ALA4382275 | small-molecule physicochemical format | Scientific Literature | ||
2. | ALA4385275 | B | Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay | Homo sapiens | 15 | ALA4382275 | cell-based format | Scientific Literature | |
3. | ALA4385276 | B | Inhibition of recombinant human HL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay | Homo sapiens | 15 | ALA4382275 | cell-based format | Scientific Literature | |
4. | ALA4385277 | B | Inhibition of recombinant human LPL expressed in COS7 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay | Homo sapiens | 2 | ALA4382275 | cell-based format | Scientific Literature | |
5. | ALA4385278 | B | Inhibition of recombinant human PL expressed in HEK293F cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins by fluorescence assay | Homo sapiens | 2 | ALA4382275 | cell-based format | Scientific Literature | |
6. | ALA4385279 | B | Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins in presence of human serum by fluorescence assay | Homo sapiens | 15 | ALA4382275 | cell-based format | Scientific Literature | |
7. | ALA4385286 | A | Cmax in overnight fasted Balb-C mouse at 10 mg/kg, po administered as single dose via gavage by LC-MS/MS analysis | Mus musculus | 2 | ALA4382275 | organism-based format | Scientific Literature | |
8. | ALA4385287 | A | Plasma concentration in overnight fasted Balb-C mouse at 10 mg/kg, po administered as single dose via gavage measured 7 hrs post dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4382275 | organism-based format | Scientific Literature | |
9. | ALA4385288 | A | Plasma concentration in overnight fasted Balb-C mouse at 10 mg/kg, po administered as single dose via gavage measured 24 hrs post dose by LC-MS/MS analysis | Mus musculus | 2 | ALA4382275 | organism-based format | Scientific Literature | |
10. | ALA4385295 | B | Inhibition of endothelial lipase in human HT1080 cells using PED-A1 containing DMPG vesicles as substrate pretreated for 20 mins followed by substrate addition and measured every 20 secs for 10 mins in presence of C57BL/6 mouse plasma by fluorescence assay | Homo sapiens | 15 | ALA4382275 | cell-based format | Scientific Literature |