# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4332321 | B | Agonist activity at EGFP-fused TrkB receptor (unknown origin) expressed in HEK293T cells assessed as increase in TrkB phosphorylation at Y705 residue at 1 uM after 10 to 15 mins by Western blot analysis | Homo sapiens | 2 | ALA4330110 | cell-based format | Scientific Literature | |
2. | ALA4332322 | B | Agonist activity at EGFP-fused TrkB receptor (unknown origin) expressed in HEK293T cells assessed as increase in TrkB phosphorylation at Y705 residue after 10 to 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4330110 | cell-based format | Scientific Literature | |
3. | ALA4332323 | B | Agonist activity at RFP-fused TrkA receptor (unknown origin) expressed in HEK293T cells assessed as increase in TrkA phosphorylation at Y490 residue at 1 uM after 10 to 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4330110 | cell-based format | Scientific Literature | |
4. | ALA4332324 | B | Agonist activity at TrkB receptor in Swiss mouse primary cortical neurons assessed as increase in TrkB phosphorylation at Y705 residue after 15 mins by Western blot analysis | Mus musculus | 1 | ALA4330110 | single protein format | Scientific Literature | |
5. | ALA4332325 | B | Agonist activity at EGFP-fused TrkB receptor (unknown origin) expressed in HEK293T cells after 6 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA4330110 | cell-based format | Scientific Literature | |
6. | ALA4332326 | B | Agonist activity at RFP-fused TrkA receptor (unknown origin) expressed in HEK293T cells after 6 hrs by luciferase reporter gene assay | Homo sapiens | 1 | ALA4330110 | cell-based format | Scientific Literature | |
7. | ALA4332327 | B | Activation of firefly luciferase activity expressed in HEK293T cells after 6 hrs by luminescence assay | Photinus pyralis | 2 | ALA4330110 | cell-based format | Scientific Literature | |
8. | ALA4332328 | B | Selectivity ratio of EC50 for RFP-fused TrkA receptor (unknown origin) expressed in HEK293T cells to EC50 for EGFP-fused TrkA receptor (unknown origin) expressed in HEK293T cells | Homo sapiens | 1 | ALA4330110 | cell-based format | Scientific Literature | |
9. | ALA4332329 | B | Agonist activity at EGFP-fused TrkB receptor (unknown origin) expressed in HEK293T cells assessed as increase in ERK1/2 phosphorylation after 15 mins by Western blot analysis | Homo sapiens | 1 | ALA4330110 | cell-based format | Scientific Literature | |
10. | ALA4332330 | B | Agonist activity at TrkB receptor in Swiss mouse primary cortical neurons assessed as increase in MAP2 expression after 72 hrs by Western blot analysis | Mus musculus | 1 | ALA4330110 | assay format | Scientific Literature | |
11. | ALA4332331 | B | Agonist activity at TrkB receptor in Swiss mouse primary cortical neurons assessed as increase in PSD95 expression after 72 hrs by Western blot analysis | Mus musculus | 1 | ALA4330110 | assay format | Scientific Literature | |
12. | ALA4332332 | B | Agonist activity at TrkB receptor in Swiss mouse primary cortical neurons transfected with AAV2 Tdtomato assessed as increase in dendritic arborization at 100 nM after 72 hrs by confocal microscopic analysis | Mus musculus | 1 | ALA4330110 | assay format | Scientific Literature |