| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4345965 | A | Stability in human liver microsomes assessed as compound remaining level incubated for 60 mins in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 5 | ALA4342517 | microsome format | Scientific Literature | |
| 2. | ALA4345966 | A | Intrinsic clearance in human liver derived from clearance in liver microsomes in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 5 | ALA4342517 | tissue-based format | Scientific Literature | |
| 3. | ALA4345967 | A | Intrinsic clearance in human liver microsomes in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 5 | ALA4342517 | microsome format | Scientific Literature | |
| 4. | ALA4345968 | A | Half life in human liver microsomes in presence of NADPH regenerating system by LC-MS/MS analysis | Homo sapiens | 5 | ALA4342517 | microsome format | Scientific Literature | |
| 5. | ALA4345969 | A | Half life in human plasma at 2 uM at 37 degC by LC-MS/MS analysis | Homo sapiens | 2 | ALA4342517 | cell-free format | Scientific Literature | |
| 6. | ALA4345970 | A | Stability in human plasma assessed as compound remaining level at 2 uM incubated for 120 mins at 37 degC by LC-MS/MS analysis | Homo sapiens | 3 | ALA4342517 | cell-free format | Scientific Literature | |
| 7. | ALA4345971 | B | Inhibition of purified recombinant HIV1 reverse transcriptase assessed as remaining enzyme activity at 0.2 uM using template/primer hybrid, digoxigenin-labeled nucleotides and biotin-labeled nucleotides incubated for 1 hr by calorimetric assay relative to control | Human immunodeficiency virus 1 | 1 | ALA4342517 | single protein format | Scientific Literature | |
| 8. | ALA4345973 | B | Inhibition of HIV1 NL4-3 capsid protein assembly at 50 uM measured every 1 min for 19 mins | Human immunodeficiency virus 1 | 3 | ALA4342517 | single protein format | Scientific Literature | |
| 9. | ALA4345974 | F | Induction of increase in CA/p24 content in HIV1 NL4-3 infected in human TZM-bl cells at 10 uM by ELISA relative to control | Human immunodeficiency virus 1 | 4 | ALA4342517 | organism-based format | Scientific Literature | |
| 10. | ALA4345975 | F | Potency index, ratio of IC50 for PF-74 to IC50 for test compound for antiviral activity against HIV1 Env-pseudotyped virus in human U87.CD4.CCR5 target cells assessed as reduction in viral infection at early stage | Human immunodeficiency virus 1 | 1 | ALA4342517 | organism-based format | Scientific Literature | |
| 11. | ALA4345976 | F | Selectivity index, ratio of IC50 for antiviral activity against HIV1 Env-pseudotyped virus in human U87.CD4.CCR5 target cells assessed as reduction in viral infection at late stage to IC50 for antiviral activity against HIV1 Env-pseudotyped virus in human U87.CD4.CCR5 target cells assessed as reduction in viral infection at early stage | Human immunodeficiency virus 1 | 4 | ALA4342517 | organism-based format | Scientific Literature | |
| 12. | ALA4345977 | F | Antiviral activity against HIV1 Env-pseudotyped virus in human U87.CD4.CCR5 target cells assessed as reduction in viral infection at late stage | Human immunodeficiency virus 1 | 4 | ALA4342517 | organism-based format | Scientific Literature | |
| 13. | ALA4345978 | F | Antiviral activity against HIV1 Env-pseudotyped virus in human U87.CD4.CCR5 target cells assessed as reduction in viral infection at early stage | Human immunodeficiency virus 1 | 4 | ALA4342517 | organism-based format | Scientific Literature | |
| 14. | ALA4345979 | B | Binding affinity to HIV1 NL4-3 capsid protein hexamer by SPR analysis | Human immunodeficiency virus 1 | 8 | ALA4342517 | single protein format | Scientific Literature | |
| 15. | ALA4345980 | B | Binding affinity to HIV1 NL4-3 capsid protein monomer by SPR analysis | Human immunodeficiency virus 1 | 8 | ALA4342517 | single protein format | Scientific Literature | |
| 16. | ALA4345981 | B | Selectivity index, ratio of Kd for binding affinity to HIV1 NL4-3 capsid protein monomer by SPR analysis to Kd for binding affinity to HIV1 NL4-3 capsid protein hexamer by SPR analysis | Human immunodeficiency virus 1 | 8 | ALA4342517 | single protein format | Scientific Literature | |
| 17. | ALA4345982 | T | Selectivity index, ratio of CC50 for cytotoxicity in human TZM-bl assessed as reduction in cell viability incubated for 1 day by Cyto-tox-Glo cytotoxicity assay to EC50 for antiviral activity against HIV1 NL4-3 infected in human TZM-bl cells assessed as reduction in virus induced cytopathogenicity incubated for 1 day by luciferase reporter gene assay | 37 | ALA4342517 | cell-based format | Scientific Literature | ||
| 18. | ALA4345983 | A | Cytotoxicity in uninfected human TZM-bl assessed as reduction in cell viability incubated for 1 day by Cyto-tox-Glo cytotoxicity assay | Homo sapiens | 38 | ALA4342517 | cell-based format | Scientific Literature | |
| 19. | ALA4345984 | F | Antiviral activity against HIV1 NL4-3 infected in human TZM-bl cells assessed as reduction in virus induced cytopathogenicity incubated for 1 day by luciferase reporter gene assay | Human immunodeficiency virus 1 | 38 | ALA4342517 | organism-based format | Scientific Literature | |
| 20. | ALA4345985 | A | Cmax in Sprague-Dawley rat at 20 mg/kg, po measured during 5 mins to 12 hrs by LC-MS analysis | Rattus norvegicus | 1 | ALA4342517 | organism-based format | Scientific Literature |
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