# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4423935 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS expression at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
2. | ALA4423936 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production by measuring nitrite levels at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Griess assay (Rvb = 32.4 +/- 0.9 uM) | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
3. | ALA4423937 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 expression at 50 uM preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
4. | ALA4423938 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced nitric oxide production preincubated for 30 mins followed by LPS challenge and measured after 18 hrs by Griess assay | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
5. | ALA4423939 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS expression preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
6. | ALA4423940 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 expression preincubated for 30 mins followed by LPS challenge and measured after 16 hrs by Western blot analysis | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
7. | ALA4423941 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced iNOS mRNA expression preincubated for 30 mins followed by LPS challenge and measured after 3 to 12 hrs by SYBR green dye based qRT-PCR analysis | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
8. | ALA4423942 | Functional | Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS induced COX2 mRNA expression preincubated for 30 mins followed by LPS challenge and measured after 3 to 12 hrs by SYBR green dye based qRT-PCR analysis | Mus musculus | 2 | ALA4422643 | cell-based format | Scientific Literature | |
9. | ALA4423945 | ADME | Effect on p38 phosphorylation at T180/Y182 residues in mouse RAW264.7 cells at 40 uM measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
10. | ALA4423946 | ADME | Effect on ERK1/2 phosphorylation at T202/Y204 residues in mouse RAW264.7 cells at 40 uM measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
11. | ALA4423947 | ADME | Effect on SAPK/JNK1/2 phosphorylation at T183/Y185 residues in mouse RAW264.7 cells at 40 uM measured after 30 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
12. | ALA4423950 | Binding | Effect on IKK-mediated IkappaBalpha degradation in LPS-stimulated mouse RAW264.7 cells at 40 uM preincubated for 30 mins followed by LPS-stimulation and measured after 10 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
13. | ALA4423951 | Binding | Effect on IKK-mediated IkappaBalpha degradation in LPS-stimulated mouse RAW264.7 cells assessed as IkappaBalpha recovery at 40 uM preincubated for 30 mins followed by LPS-stimulation and measured after 20 to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
14. | ALA4423954 | Binding | Inhibition of LPS-induced AKT phosphorylation at S473 residue in mouse RAW264.7 cells at 40 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
15. | ALA4423955 | ADME | Effect on total AKT expression in LPS-stimulated mouse RAW264.7 cells at 40 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
16. | ALA4423958 | Binding | Inhibition of LPS-induced STAT1 phosphorylation at Y701 residue in mouse RAW264.7 cells at 40 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature | |
17. | ALA4423959 | ADME | Effect on total STAT1 expression in LPS-stimulated mouse RAW264.7 cells at 40 uM preincubated for 30 mins followed by LPS-stimulation and measured up to 240 mins by Western blot analysis | Mus musculus | 1 | ALA4422643 | cell-based format | Scientific Literature |