| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4373557 | B | Induction of conformational changes in human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) assessed as ion population arrival time distribution at 2 uM after 20 hrs by ion mobility-mass spectrometry analysis (Rvb = 5.23 milliseconds) | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 2. | ALA4373558 | U | Self fibrillation of the compound in pH 7.4 ammonium acetate buffer after 100 hrs by ThT fluorescence assay | 1 | ALA4371098 | assay format | Scientific Literature | ||
| 3. | ALA4373559 | B | Inhibition of fibril formation of human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) after 100 hrs by ThT fluorescence assay | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 4. | ALA4373560 | B | Inhibition of fibril formation of human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) at protein to compound molar ratio of 200:1 after 100 hrs by ThT fluorescence assay relative to control | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 5. | ALA4373561 | B | Inhibition of preformed fibrils of human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) at 5 uM treated after 60 hrs during fibril elongation phase by ThT fluorescence assay | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 6. | ALA4373562 | B | Inhibition of fibril formation of human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) assessed as reduction in mature fibrils formation at 2 uM after 100 hrs by uranyl acetate staining based transmission electron microscopic method | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 7. | ALA4373563 | B | Inhibition of amyloid beta (1 to 40) (unknown origin) fibril formation at 2 uM after 25 hrs by uranyl acetate staining based transmission electron microscopic method | Homo sapiens | 1 | ALA4371098 | single protein format | Scientific Literature | |
| 8. | ALA4373564 | B | Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation at 2 uM after 2 hrs by uranyl acetate staining based transmission electron microscopic method | Homo sapiens | 1 | ALA4371098 | single protein format | Scientific Literature | |
| 9. | ALA4373565 | B | Inhibition of amyloid beta (1 to 40) (unknown origin) fibril formation at protein to compound ratio of 5:1 after 100 hrs by ThT fluorescence assay | Homo sapiens | 1 | ALA4371098 | single protein format | Scientific Literature | |
| 10. | ALA4373566 | B | Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation at protein to compound ratio of 5:1 after 100 hrs by ThT fluorescence assay | Homo sapiens | 1 | ALA4371098 | single protein format | Scientific Literature | |
| 11. | ALA4373567 | B | Inhibition of heat-induced amorphous aggregation of yeast ADH at 2.5 uM measured over 2 hrs by light scattering assay | Saccharomyces cerevisiae | 1 | ALA4371098 | assay format | Scientific Literature | |
| 12. | ALA4373568 | B | Inhibition of heat-induced amorphous aggregation of bovine liver catalase at 2.5 uM measured over 2 hrs by light scattering assay | Bos taurus | 1 | ALA4371098 | assay format | Scientific Literature | |
| 13. | ALA4373569 | B | Binding affinity to human 15N-labeled alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) assessed as chemical perturbation at H50 at 7.5 uM by 2D 1H-15N HSQC NMR analysis | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 14. | ALA4373570 | B | Binding affinity to human 15N-labeled alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) assessed as reduction in signal to noise ratio at 7.5 uM by 2D 1H-15N HSQC NMR analysis | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 15. | ALA4373571 | B | Binding affinity to human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) assessed as compound-protein stable complex formation at 2 uM after 20 hrs by native mass spectrometry analysis | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 16. | ALA4373572 | B | Binding affinity to human alpha-synuclein A53T mutant expressed in Escherichia coli BL21(DE3) assessed as compound-protein stable complex formation at 2 uM after 20 hrs by size-exclusion chromatographic method | Homo sapiens | 1 | ALA4371098 | assay format | Scientific Literature | |
| 17. | ALA4617179 | F | Cytotoxicity against human LNCAP cells assessed as reduction in cell viability at 500 ug/mL after 24 hrs by trypan blue dye exclusion assay | Homo sapiens | 1 | ALA4616599 | cell-based format | Scientific Literature | |
| 18. | ALA4617181 | F | Cytotoxicity against human LNCAP cells assessed as reduction in cell viability at 500 ug/ml measured after 24 hrs in presence of topotecan by trypan blue dye exclusion test relative to control | Homo sapiens | 1 | ALA4616599 | cell-based format | Scientific Literature | |
| 19. | ALA4617182 | F | Down regulation of BIRC5 gene expression in human LNCAP cells at 500 ug/ml measured after 24 hrs by RT profile PCR analysis relative to control | Homo sapiens | 1 | ALA4616599 | cell-based format | Scientific Literature | |
| 20. | ALA4617183 | F | Down regulation of BCL2 gene expression in human LNCAP cells at 500 ug/ml measured after 24 hrs by RT profile PCR analysis relative to control | Homo sapiens | 1 | ALA4616599 | cell-based format | Scientific Literature |
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