# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4428507 | Binding | Inhibition of CRT CVIET haplotype mutant in Plasmodium falciparum K1 isolate MRA-159 infected in erythrocytes assessed as chloroquine-coumarin probe accumulation at 10 uM after 10 hrs by Hoechst 33342 staining based flow cytometry (Rvb = 35.57 +/- 3.84%) | Plasmodium falciparum K1 | 38 | ALA4428038 | cell-based format | Scientific Literature | |
2. | ALA4428509 | Functional | Potentiation of chloroquine-induced antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 isolate MRA-102 assessed as reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | organism-based format | Scientific Literature | |
3. | ALA4428510 | Functional | Potentiation of chloroquine-induced antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 isolate MRA-155 assessed as reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | organism-based format | Scientific Literature | |
4. | ALA4428511 | Binding | Inhibition of CRT SVMNT haplotype mutant in intermediate chloroquine-resistant Plasmodium falciparum 7G8 isolate MRA-154 t assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum 7G8 | 11 | ALA4428038 | assay format | Scientific Literature | |
5. | ALA4428512 | Binding | Inhibition of CRT CVIET haplotype mutant in chloroquine-resistant Plasmodium falciparum K1 isolate MRA-159 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum K1 | 11 | ALA4428038 | assay format | Scientific Literature | |
6. | ALA4428513 | Binding | Inhibition of CRT K76T mutant in chloroquine-resistant Plasmodium falciparum Dd2 isolate MRA-156 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum Dd2 | 11 | ALA4428038 | single protein format | Scientific Literature | |
7. | ALA4428514 | Binding | Inhibition of CRT K76T mutant in chloroquine/artemisinin-resistant Plasmodium falciparum ARS233 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
8. | ALA4428515 | Binding | Inhibition of CRT K76T mutant in chloroquine/artemisinin-resistant Plasmodium falciparum ARS272 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
9. | ALA4428516 | Binding | Inhibition of CRT K76T mutant in chloroquine-resistant Plasmodium falciparum NHP4559 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
10. | ALA4428517 | Binding | Inhibition of CRT K76T mutant in chloroquine/artemisinin-resistant Plasmodium falciparum NHP4773 assessed as reversal of chloroquine resistance by measuring reduction in chloroquine IC50 at 500 nM relative to chloroquine alone | Plasmodium falciparum | 11 | ALA4428038 | single protein format | Scientific Literature | |
11. | ALA4428518 | Functional | Intrinsic antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 isolate MRA-102 assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
12. | ALA4428519 | Functional | Intrinsic antimalarial activity against chloroquine-sensitive Plasmodium falciparum HB3 isolate MRA-155 assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
13. | ALA4428520 | Functional | Intrinsic antimalarial activity against intermediate chloroquine-resistant Plasmodium falciparum 7G8 isolate MRA-154 harboring CRT SVMNT haplotype mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
14. | ALA4428521 | Functional | Intrinsic antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 isolate MRA-159 harboring CRT CVIET haplotype mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
15. | ALA4428522 | Functional | Intrinsic antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 isolate MRA-156 harboring CRT K76T mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
16. | ALA4428523 | Functional | Intrinsic antimalarial activity against chloroquine/artemisinin-resistant Plasmodium falciparum ARS233 harboring CRT K76T mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
17. | ALA4428524 | Functional | Intrinsic antimalarial activity against chloroquine/artemisinin-resistant Plasmodium falciparum ARS272 harboring CRT K76T mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
18. | ALA4428525 | Functional | Intrinsic antimalarial activity against chloroquine-resistant Plasmodium falciparum NHP4559 harboring CRT K76T mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
19. | ALA4428526 | Functional | Intrinsic antimalarial activity against chloroquine/artemisinin-resistant Plasmodium falciparum NHP4773 harboring CRT K76T mutant assessed as reduction in parasite viability at 500 nM | Plasmodium falciparum | 37 | ALA4428038 | organism-based format | Scientific Literature | |
20. | ALA4428527 | Unassigned | Resistance index, ratio of chloroquine IC50 for intermediate chloroquine-resistant Plasmodium falciparum 7G8 isolate MRA-154 CRT SVMNT haplotype mutant to chloroquine IC50 for chloroquine-sensitive Plasmodium falciparum 3D7 isolate MRA-102 at 500 nM | 11 | ALA4428038 | assay format | Scientific Literature |
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