# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4391927 | B | Inhibition of human recombinant AChE using acetylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method | Homo sapiens | 31 | ALA4390667 | single protein format | Scientific Literature | |
2. | ALA4391928 | B | Inhibition of human recombinant BChE using butyrylthiocholine iodide as substrate preincubated for 5 mins followed by substrate addition and measured over 2 mins by UV-Vis spectrophotometric analysis based Ellman's method | Homo sapiens | 31 | ALA4390667 | single protein format | Scientific Literature | |
3. | ALA4391929 | B | Selectivity index, ratio of IC50 for recombinant human BChE to IC50 for recombinant human AChE | Homo sapiens | 31 | ALA4390667 | protein format | Scientific Literature | |
4. | ALA4391930 | B | Inhibition of HFIP pretreated amyloid beta (1-42) (unknown origin) self aggregation at 50 uM incubated for 24 hrs by thioflavin T based fluorescence assay relative to control | Homo sapiens | 30 | ALA4390667 | single protein format | Scientific Literature | |
5. | ALA4391932 | A | Effective permeability of the compound in PBS buffer at pH 7.4 at 100 uM after 3 to 6 hrs by PAMPA | 23 | ALA4390667 | assay format | Scientific Literature | ||
6. | ALA4391936 | A | Cytotoxicity against CHOK1 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Cricetulus griseus | 27 | ALA4390667 | cell-based format | Scientific Literature | |
7. | ALA4391937 | A | Cytotoxicity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay | Homo sapiens | 27 | ALA4390667 | cell-based format | Scientific Literature | |
8. | ALA4391939 | B | Inhibition of nNOS in Wistar rat cortical homogenates incubated for 30 mins | Rattus norvegicus | 26 | ALA4390667 | assay format | Scientific Literature |