| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4340054 | B | Binding affinity to C-terminal His tagged purified recombinant PCSK9 D374Y mutant (unknown origin) expressed in HEK293 cells assessed as dose dependent reduction in PCSK9/LDLR protein-protein interaction at 0.1 uM to 1 mM uM by chemiluminescent assay | Homo sapiens | 3 | ALA4339215 | cell-based format | Scientific Literature | |
| 2. | ALA4340058 | B | Inhibition of C-terminal His tagged purified recombinant PCSK9 D374Y mutant (unknown origin) and LDLR protein-protein interaction expressed in human HepG2 cells assessed as LDLR protein expression level at cell surface at 350 uM incubated for 2 hrs by in-cell western analysis (Rvb = 39.6 +/- 0.7%) | Homo sapiens | 1 | ALA4339215 | cell-based format | Scientific Literature | |
| 3. | ALA5236424 | B | Inhibition of PCSK9-LDLR (unknown origin) protein-protein interaction | Homo sapiens | 9 | ALA5233285 | protein format | Scientific Literature | |
| 4. | ALA5236425 | B | Inhibition of PCSK9-LDLR protein-protein interaction in human HepG2 cells assessed as restoration of LDLR at 350 uM | Homo sapiens | 1 | ALA5233285 | cell-based format | Scientific Literature | |
| 5. | ALA5236426 | B | Inhibition of PCSK9-LDLR protein-protein interaction in human HepG2 cells assessed as increase in LDL uptake at 350 uM | Homo sapiens | 1 | ALA5233285 | cell-based format | Scientific Literature |
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