# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4370880 | B | Agonist activity at Nurr1 in mouse N2A cells harboring NBRE by luciferase reporter gene assay | Mus musculus | 17 | ALA4368940 | cell-based format | Scientific Literature | |
2. | ALA4370881 | B | Agonist activity at full-length Gal4-fused NOT (unknown origin) expressed in CHO cells by luciferase reporter gene assay | Homo sapiens | 49 | ALA4368940 | cell-based format | Scientific Literature | |
3. | ALA4370882 | B | Agonist activity at Nurr1 in rat mesencephalic primary neurons assessed as increase in tyrosine hydroxylase expression at 3 uM | Rattus norvegicus | 3 | ALA4368940 | assay format | Scientific Literature | |
4. | ALA4370883 | B | Agonist activity at Nurr1 in mouse MG7 cells assessed as inhibition of LPS-induced IL1beta secretion at 3 uM | Mus musculus | 3 | ALA4368940 | cell-based format | Scientific Literature | |
5. | ALA4370884 | B | Agonist activity at Nurr1 in mouse MG7 cells assessed as inhibition of LPS-induced neurotoxicity by measuring neuroprotection at 3 uM | Mus musculus | 3 | ALA4368940 | cell-based format | Scientific Literature | |
6. | ALA4370885 | B | Agonist activity at Nurr1 in mouse MG7 cells assessed as inhibition of LPS-induced neurotoxicity by measuring neuroprotection at 10 uM | Mus musculus | 2 | ALA4368940 | cell-based format | Scientific Literature | |
7. | ALA4370886 | P | Solubility of the compound by HPLC analysis | 2 | ALA4368940 | small-molecule physicochemical format | Scientific Literature | ||
8. | ALA4370887 | A | Stability in human plasma | Homo sapiens | 2 | ALA4368940 | cell-free format | Scientific Literature | |
9. | ALA4370888 | A | Stability in mouse plasma | Mus musculus | 2 | ALA4368940 | cell-free format | Scientific Literature | |
10. | ALA4370889 | P | Lipophilicity, log D of the compound | 2 | ALA4368940 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4370890 | P | Dissociation constant, pKa of the compound | 2 | ALA4368940 | small-molecule physicochemical format | Scientific Literature | ||
12. | ALA4370891 | A | Apparent permeability in human Caco2 cells | Homo sapiens | 2 | ALA4368940 | cell-based format | Scientific Literature | |
13. | ALA4370892 | A | Drug metabolism in mouse liver microsomes | Mus musculus | 2 | ALA4368940 | microsome format | Scientific Literature | |
14. | ALA4370893 | A | Drug metabolism in human liver microsomes | Homo sapiens | 2 | ALA4368940 | microsome format | Scientific Literature | |
15. | ALA4370894 | A | Clearance in human hepatocytes assessed per million cells | Homo sapiens | 6 | ALA4368940 | cell-based format | Scientific Literature | |
16. | ALA4370895 | A | Inhibition of CYP3A4 (unknown origin) | Homo sapiens | 2 | ALA4368940 | single protein format | Scientific Literature | |
17. | ALA4370896 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 2 | ALA4368940 | single protein format | Scientific Literature | |
18. | ALA4370897 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 2 | ALA4368940 | single protein format | Scientific Literature | |
19. | ALA4370898 | A | Induction of CYP450 (unknown origin) | Homo sapiens | 2 | ALA4368940 | protein format | Scientific Literature | |
20. | ALA4370899 | B | Activation of human ERG | Homo sapiens | 2 | ALA4368940 | single protein format | Scientific Literature |