# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4385229 | A | Inhibition of XBP ATPase activity in human HeLa cell nuclear extracts | Homo sapiens | 2 | ALA4382274 | cell-based format | Scientific Literature | |
2. | ALA4385230 | F | Cytotoxicity against human HepG2 cells after 48 hrs by XTT assay | Homo sapiens | 2 | ALA4382274 | cell-based format | Scientific Literature | |
3. | ALA4385231 | A | Cytotoxicity against primary hepatocytes (unknown origin) after 48 hrs by XTT assay | Not specified | 2 | ALA4382274 | cell-based format | Scientific Literature | |
4. | ALA4385232 | T | Therapeutic index, ratio of IC50 for primary hepatocytes (unknown origin) to IC50 for human HepG2 cells | Homo sapiens | 1 | ALA4382274 | assay format | Scientific Literature | |
5. | ALA4385234 | F | Cytotoxicity against human HepG2 cells after 48 hrs in presence of NQO1 inhibitor dicoumarol by XTT assay | Homo sapiens | 1 | ALA4382274 | cell-based format | Scientific Literature | |
6. | ALA4385235 | A | Half life in human HepG2 cell lysates assessed as NQO1-mediated compound degradation at 10 uM in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4382274 | subcellular format | Scientific Literature | |
7. | ALA4385236 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated CX-21 formation at 10 uM up to 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4382274 | subcellular format | Scientific Literature | |
8. | ALA4385237 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated triptolide formation at 10 uM up to 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4382274 | subcellular format | Scientific Literature | |
9. | ALA4385238 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated CX-21 formation at 10 uM after 60 mins in presence of NADPH and NQO1 inhibitor dicoumarol by HPLC analysis | Homo sapiens | 1 | ALA4382274 | subcellular format | Scientific Literature | |
10. | ALA4385239 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated triptolide formation at 10 uM after 60 mins in presence of NADPH and NQO1 inhibitor dicoumarol by HPLC analysis | Homo sapiens | 1 | ALA4382274 | subcellular format | Scientific Literature | |
11. | ALA4385240 | A | Prodrug activation assessed as recombinant NQO1 (unknown origin)-mediated triptolide formation by measuring compound apparent Km after 20 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4382274 | single protein format | Scientific Literature | |
12. | ALA4385241 | A | Prodrug activation assessed as recombinant NQO1 (unknown origin)-mediated triptolide formation by measuring compound apparent Vmax after 20 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | ALA4382274 | single protein format | Scientific Literature | |
13. | ALA4385242 | A | Cytotoxicity against human keratinocytes after 48 hrs by XTT assay | Homo sapiens | 1 | ALA4382274 | cell-based format | Scientific Literature | |
14. | ALA4385243 | A | Cytotoxicity against human skin fibroblasts after 48 hrs by XTT assay | Homo sapiens | 1 | ALA4382274 | assay format | Scientific Literature | |
15. | ALA4385244 | F | Cytotoxicity against human HeLa cells after 48 hrs by XTT assay | Homo sapiens | 1 | ALA4382274 | cell-based format | Scientific Literature | |
16. | ALA4385245 | F | Cytotoxicity against human A549 cells after 48 hrs by XTT assay | Homo sapiens | 1 | ALA4382274 | cell-based format | Scientific Literature | |
17. | ALA4385246 | A | Half life in human plasma assessed as carboxyl ester hydrolase-mediated compound degradation at 10 uM by UV-HPLC analysis | Homo sapiens | 1 | ALA4382274 | cell-free format | Scientific Literature | |
18. | ALA4385247 | A | Half life in human liver microsomes assessed as CYP450-mediated compound degradation at 10 uM by UV-HPLC analysis | Homo sapiens | 1 | ALA4382274 | microsome format | Scientific Literature | |
19. | ALA4385248 | A | Absorption half life in KM mouse at 1 mg/kg, ip administered as single dose | Mus musculus | 1 | ALA4382274 | organism-based format | Scientific Literature | |
20. | ALA4385249 | A | Tmax in KM mouse at 1 mg/kg, ip administered as single dose | Mus musculus | 1 | ALA4382274 | organism-based format | Scientific Literature |