| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4385229 | A | Inhibition of XBP ATPase activity in human HeLa cell nuclear extracts | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 2. | ALA4385230 | F | Cytotoxicity against human HepG2 cells after 48 hrs by XTT assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4385231 | A | Cytotoxicity against primary hepatocytes (unknown origin) after 48 hrs by XTT assay | Not specified | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4385232 | T | Therapeutic index, ratio of IC50 for primary hepatocytes (unknown origin) to IC50 for human HepG2 cells | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 5. | ALA4385234 | F | Cytotoxicity against human HepG2 cells after 48 hrs in presence of NQO1 inhibitor dicoumarol by XTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4385235 | A | Half life in human HepG2 cell lysates assessed as NQO1-mediated compound degradation at 10 uM in presence of NADPH by HPLC analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 7. | ALA4385236 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated CX-21 formation at 10 uM up to 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 8. | ALA4385237 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated triptolide formation at 10 uM up to 60 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 9. | ALA4385238 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated CX-21 formation at 10 uM after 60 mins in presence of NADPH and NQO1 inhibitor dicoumarol by HPLC analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 10. | ALA4385239 | A | Prodrug activation in human HepG2 cell lysates assessed as NQO1-mediated triptolide formation at 10 uM after 60 mins in presence of NADPH and NQO1 inhibitor dicoumarol by HPLC analysis | Homo sapiens | 1 | subcellular format | Scientific Literature | ||
| 11. | ALA4385240 | A | Prodrug activation assessed as recombinant NQO1 (unknown origin)-mediated triptolide formation by measuring compound apparent Km after 20 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 12. | ALA4385241 | A | Prodrug activation assessed as recombinant NQO1 (unknown origin)-mediated triptolide formation by measuring compound apparent Vmax after 20 mins in presence of NADPH by HPLC analysis | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 13. | ALA4385242 | A | Cytotoxicity against human keratinocytes after 48 hrs by XTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4385243 | A | Cytotoxicity against human skin fibroblasts after 48 hrs by XTT assay | Homo sapiens | 1 | assay format | Scientific Literature | ||
| 15. | ALA4385244 | F | Cytotoxicity against human HeLa cells after 48 hrs by XTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4385245 | F | Cytotoxicity against human A549 cells after 48 hrs by XTT assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 17. | ALA4385246 | A | Half life in human plasma assessed as carboxyl ester hydrolase-mediated compound degradation at 10 uM by UV-HPLC analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 18. | ALA4385247 | A | Half life in human liver microsomes assessed as CYP450-mediated compound degradation at 10 uM by UV-HPLC analysis | Homo sapiens | 1 | microsome format | Scientific Literature | ||
| 19. | ALA4385248 | A | Absorption half life in KM mouse at 1 mg/kg, ip administered as single dose | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 20. | ALA4385249 | A | Tmax in KM mouse at 1 mg/kg, ip administered as single dose | Mus musculus | 1 | organism-based format | Scientific Literature |
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