| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4382297 | B | Inhibition of GST-tagged human ALK cytoplasmic domain (1058 to 1620 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | Homo sapiens | 15 | ALA4382192 | assay format | Scientific Literature | |
| 2. | ALA4382298 | B | Inhibition of wild type GST-tagged human EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | Homo sapiens | 15 | ALA4382192 | assay format | Scientific Literature | |
| 3. | ALA4382299 | B | Inhibition of GST-tagged human EGFR T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | Homo sapiens | 15 | ALA4382192 | assay format | Scientific Literature | |
| 4. | ALA4382300 | B | Inhibition of GST-tagged human EGFR T790M/L858R double mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using Poly G:T (4:1) as substrate after 30 mins by Z-LYTE assay | Homo sapiens | 15 | ALA4382192 | assay format | Scientific Literature | |
| 5. | ALA4382301 | B | Inhibition of EGFR L858R mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 16 | ALA4382192 | cell-based format | Scientific Literature | |
| 6. | ALA4382302 | B | Inhibition of EGFR exon19 deletion mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 15 | ALA4382192 | cell-based format | Scientific Literature | |
| 7. | ALA4382303 | B | Inhibition of EGFR T790M exon19 deletion double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 15 | ALA4382192 | cell-based format | Scientific Literature | |
| 8. | ALA4382304 | B | Inhibition of EML4/ALK (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 15 | ALA4382192 | cell-based format | Scientific Literature | |
| 9. | ALA4382305 | A | Antiproliferative activity against mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Mus musculus | 15 | ALA4382192 | cell-based format | Scientific Literature | |
| 10. | ALA4382306 | B | Inhibition of wild type EGFR (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 15 | ALA4382192 | cell-based format | Scientific Literature | |
| 11. | ALA4382307 | B | Inhibition of EGFR T790M/L858R double mutant (unknown origin) transfected in mouse BAF3 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 16 | ALA4382192 | cell-based format | Scientific Literature | |
| 12. | ALA4382308 | B | Selectivity ratio of EC50 for wild type EGFR (unknown origin) to EC50 for EGFR L858R mutant (unknown origin) | Homo sapiens | 1 | ALA4382192 | assay format | Scientific Literature | |
| 13. | ALA4382309 | B | Selectivity ratio of EC50 for wild type EGFR (unknown origin) to EC50 for EGFR exon19 deletion mutant (unknown origin) | Homo sapiens | 1 | ALA4382192 | assay format | Scientific Literature | |
| 14. | ALA4382310 | B | Selectivity ratio of EC50 for wild type EGFR (unknown origin) to EC50 for EGFR T790M exon19 deletion double mutant (unknown origin) | Homo sapiens | 1 | ALA4382192 | assay format | Scientific Literature | |
| 15. | ALA4382311 | B | Selectivity ratio of EC50 for wild type EGFR (unknown origin) to EC50 for EGFR T790M/L858R double mutant (unknown origin) | Homo sapiens | 1 | ALA4382192 | assay format | Scientific Literature | |
| 16. | ALA4382312 | B | Inhibition of EML4/ALK/EGFR in human DFCI032 cells assessed as cell growth inhibition after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382192 | cell-based format | Scientific Literature | |
| 17. | ALA4382315 | B | Potency index, ratio of compound EC50 in presence of ceritinib to ceritinib EC50 when treated alone for EML4/ALK in human DFCI032 cells | Homo sapiens | 1 | ALA4382192 | cell-based format | Scientific Literature | |
| 18. | ALA4382316 | B | Potency index, ratio of compound EC50 in presence of osimertinib to osimertinib EC50 when treated alone for EML4/ALK in human DFCI032 cells | Homo sapiens | 1 | ALA4382192 | cell-based format | Scientific Literature | |
| 19. | ALA4382319 | B | Inhibition of EGFR/ALK L1152R mutant in human DFCI076 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382192 | cell-based format | Scientific Literature | |
| 20. | ALA4382320 | B | Potency index, ratio of osimertinib and ceritinib EC50 to test compound EC50 for EGFR/ALK L1152R mutant in human DFCI032 cells assessed as reduction in cell viability after 72 hrs by MTS assay | Homo sapiens | 1 | ALA4382192 | cell-based format | Scientific Literature |
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