# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4410511 | F | Antimetastatic activity against luciferase-tagged human HT1080 cells xenografted in NSG mouse assessed as reduction in lung burden at 7.5 mg/kg/day, ip for 21 days by luciferase assay relative to control | Homo sapiens | 1 | ALA4406892 | organism-based format | Scientific Literature | |
2. | ALA4410512 | B | Inhibition of human kidney uPA using fluorogenic Z-Pyr-Gly-Arg-MCA as substrate measured after 15 mins by fluorometric analysis | Homo sapiens | 22 | ALA4406892 | single protein format | Scientific Literature | |
3. | ALA4410513 | B | Inhibition of human plasma kallikrein using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
4. | ALA4410514 | B | Inhibition of human kidney uPA using chromogenic H-D-Ile-L-propyl-L-arginine-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
5. | ALA4410515 | B | Inhibition of tissue-type plasminogen activator (unknown origin) using chromogenic H-D-Ile-L-propyl-L-arginine-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
6. | ALA4410516 | B | Inhibition of plasmin (unknown origin) using chromogenic H-D-Ile-L-propyl-L-arginine-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
7. | ALA4410517 | B | Inhibition of thrombin (unknown origin) using chromogenic H-D-Ile-L-propyl-L-arginine-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
8. | ALA4410518 | B | Inhibition of trypsin (unknown origin) using chromogenic H-D-Ile-L-propyl-L-arginine-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | protein format | Scientific Literature | |
9. | ALA4410519 | B | Inhibition of factor Xa (unknown origin) | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
10. | ALA4410520 | B | Inhibition of factor 11a (unknown origin) using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
11. | ALA4410521 | B | Inhibition of activated protein C (unknown origin) using chromogenic L-pyroGlu-L-Pro-L-Arg-p-nitroaniline as substrate | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
12. | ALA4410522 | A | Cytotoxicity against human MDA-MB-231 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
13. | ALA4410523 | A | Cytotoxicity against human HepG2 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
14. | ALA4410524 | A | Cytotoxicity against human HEK293 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
15. | ALA4410525 | A | Cytotoxicity against human HT1080 cells measured after 48 hrs by MTS assay | Homo sapiens | 3 | ALA4406892 | cell-based format | Scientific Literature | |
16. | ALA4410526 | B | Inhibition of mouse uPA | Mus musculus | 2 | ALA4406892 | single protein format | Scientific Literature | |
17. | ALA4410527 | B | Inhibition of human uPA | Homo sapiens | 2 | ALA4406892 | single protein format | Scientific Literature | |
18. | ALA4410528 | B | Selectivity index, ratio of IC50 for mouse uPA to IC50 for human uPA | 1 | ALA4406892 | assay format | Scientific Literature | ||
19. | ALA4410532 | A | Diuretic activity in Sprague-Dawley rat model of acetazolamide-induced diuresis assessed as increase in urine volume at 1.5 mg/kg, ip pretreated with acetazolamide followed by compound treatment measured after 6 hrs | Rattus norvegicus | 1 | ALA4406892 | organism-based format | Scientific Literature | |
20. | ALA4410533 | A | Diuretic activity in Sprague-Dawley rat model of acetazolamide-induced diuresis assessed as increase in sodium excretion at 1.5 mg/kg, ip pretreated with acetazolamide followed by compound treatment measured after 6 hrs | Rattus norvegicus | 2 | ALA4406892 | organism-based format | Scientific Literature |