| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4424848 | B | Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins followed by substrate addition and measured after 10 mins by HTRF assay | Homo sapiens | 21 | ALA4422686 | single protein format | Scientific Literature | |
| 2. | ALA4424849 | B | Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-stimulation and measured after 6 hrs by ELISA | Mus musculus | 21 | ALA4422686 | single protein format | Scientific Literature | |
| 3. | ALA4424850 | P | Aqueous solubility of the compound in pH 7.2 phosphate buffered saline | 21 | ALA4422686 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA4424851 | A | Stability in human liver S9 fraction assessed as parent compound remaining at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 21 | ALA4422686 | subcellular format | Scientific Literature | |
| 5. | ALA4424852 | A | Stability in Sprague-Dawley rat liver S9 fraction assessed as parent compound remaining at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 21 | ALA4422686 | subcellular format | Scientific Literature | |
| 6. | ALA4424853 | A | Stability in CD-1 mouse liver S9 fraction assessed as parent compound remaining at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Mus musculus | 21 | ALA4422686 | subcellular format | Scientific Literature | |
| 7. | ALA4424854 | F | Invivo inhibition of CSF1R in CSF1-induced DBA/1J mouse assessed as reduction in LPS-induced IL6 production at 10 mg/kg, po treated for 1 hr prior to CSF1-stimulation followed by LPS-addition and measured after 2 hrs by ELISA relative to control | Mus musculus | 21 | ALA4422686 | organism-based format | Scientific Literature | |
| 8. | ALA4424855 | F | Invivo inhibition of CSF1R in CSF1-induced DBA/1J mouse assessed as reduction in LPS-induced IL6 production at 10 mg/kg, po treated for 6 hrs prior to CSF1-stimulation followed by LPS-addition and measured after 2 hrs by ELISA relative to control | Mus musculus | 21 | ALA4422686 | organism-based format | Scientific Literature |
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