# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4364013 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial cell growth by resazurin reduction method | Mycobacterium tuberculosis | 13 | ALA4359928 | organism-based format | Scientific Literature | |
2. | ALA4364014 | B | Inhibition of DprE1 in Mycobacterium tuberculosis | Mycobacterium tuberculosis | 9 | ALA4359928 | assay format | Scientific Literature | |
3. | ALA4364015 | F | Bactericidal activity against Mycobacterium tuberculosis | Mycobacterium tuberculosis | 2 | ALA4359928 | organism-based format | Scientific Literature | |
4. | ALA4364016 | F | Bactericidal activity against Mycobacterium tuberculosis infected in mouse assessed as reduction in colony forming unit at 1 to 2 times of antimycobacterial MIC incubated for 10 days | Mycobacterium tuberculosis | 1 | ALA4359928 | organism-based format | Scientific Literature | |
5. | ALA4364017 | F | Bactericidal activity against Mycobacterium tuberculosis infected in human THP1 cells assessed as reduction in colony forming unit at antimycobacterial MIC incubated for 7 days | Mycobacterium tuberculosis | 1 | ALA4359928 | organism-based format | Scientific Literature | |
6. | ALA4364018 | F | Antimycobacterial activity against Mycobacterium smegmatis mc2 155 assessed as reduction in bacterial cell growth by resazurin reduction method | Mycolicibacterium smegmatis | 1 | ALA4359928 | organism-based format | Scientific Literature | |
7. | ALA4364019 | A | Tmax in mouse at MIC in presence of CYP pan inhibitor 1-aminobenzotriazole | Mus musculus | 1 | ALA4359928 | assay format | Scientific Literature | |
8. | ALA4364020 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv overexpressing DprE1 assessed as reduction in bacterial cell growth | Mycobacterium tuberculosis | 4 | ALA4359928 | organism-based format | Scientific Literature | |
9. | ALA4364021 | F | Antimycobacterial activity against BTZ043-resistant Mycobacterium tuberculosis H37Rv harbouring DprE1 C387G mutant assessed as reduction in bacterial cell growth | Mycobacterium tuberculosis | 4 | ALA4359928 | organism-based format | Scientific Literature | |
10. | ALA4364022 | F | Antimycobacterial activity against 1,4-azaindole resistant Mycobacterium tuberculosis H37Rv harbouring DprE1 Y314H mutant assessed as reduction in bacterial cell growth | Mycobacterium tuberculosis | 4 | ALA4359928 | organism-based format | Scientific Literature | |
11. | ALA4364023 | F | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv harbouring DprE1 Y314S mutant assessed as reduction in bacterial cell growth | Mycobacterium tuberculosis | 4 | ALA4359928 | organism-based format | Scientific Literature | |
12. | ALA4364024 | P | Lipophilicity, logD of compound | 3 | ALA4359928 | small-molecule physicochemical format | Scientific Literature | ||
13. | ALA4364025 | P | Aqueous solubility of DMSO-dried solid compounds | 3 | ALA4359928 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4364026 | A | Protein binding in human plasma assessed as free fraction | Homo sapiens | 3 | ALA4359928 | cell-free format | Scientific Literature | |
15. | ALA4364027 | A | Permeability across apical to basolateral side in human Caco2 cells | Homo sapiens | 3 | ALA4359928 | cell-based format | Scientific Literature | |
16. | ALA4364028 | A | Permeability across basolateral to apical side in human Caco2 cells | Homo sapiens | 3 | ALA4359928 | cell-based format | Scientific Literature | |
17. | ALA4364029 | A | Inhibition of CYP1A2 (unknown origin) | Homo sapiens | 3 | ALA4359928 | single protein format | Scientific Literature | |
18. | ALA4364030 | A | Inhibition of CYP2C9 (unknown origin) | Homo sapiens | 3 | ALA4359928 | single protein format | Scientific Literature | |
19. | ALA4364031 | A | Inhibition of CYP2C19 (unknown origin) | Homo sapiens | 3 | ALA4359928 | single protein format | Scientific Literature | |
20. | ALA4364032 | A | Inhibition of CYP2D6 (unknown origin) | Homo sapiens | 3 | ALA4359928 | single protein format | Scientific Literature |