# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4416899 | A | Tmax in Sprague-Dawley (RjHan:SD) rat at 3 mg/kg, po administered via gavage by LC-MS analysis | Rattus norvegicus | 3 | ALA4414645 | organism-based format | Scientific Literature | |
2. | ALA4416900 | A | Inhibition of recombinant human CYP2J2 expressed in baculovirus infected insect cells co-expressing NADPH-CYP reductase and cytochrome b5 assessed as reduction in CYP2J2-mediated EPA epoxidation by measuring sum of EEQ and DiHETEs level at 1 to 50 uM using EPA as substrate preincubated for 5 mins followed by NADPH addition and measured after 15 mins by LCMS/MS analysis | Homo sapiens | 6 | ALA4414645 | cell-based format | Scientific Literature | |
3. | ALA4416901 | B | Inhibition of N-terminal His-tagged recombinant human soluble epoxide hydrolase (2 to 555 residues) expressed in Sf21 insect cells at 1 uM using as 14,15-EET as substrate after 10 mins by reversed-phase HPLC assay relative to control | Homo sapiens | 23 | ALA4414645 | cell-based format | Scientific Literature | |
4. | ALA4416902 | B | Inhibition of N-terminal His-tagged recombinant human soluble epoxide hydrolase (2 to 555 residues) expressed in Sf21 insect cells at 10 uM using as 14,15-EET as substrate after 10 mins by reversed-phase HPLC assay relative to control | Homo sapiens | 22 | ALA4414645 | cell-based format | Scientific Literature | |
5. | ALA4416903 | F | Negative chronotropic activity in Wistar rat neonatal cardiomyocytes assessed as change in basal beating rate after 7 mins by inverted microscopic method | Rattus norvegicus | 20 | ALA4414645 | cell-based format | Scientific Literature | |
6. | ALA4416904 | F | Negative chronotropic activity in Wistar rat neonatal cardiomyocytes assessed as decrease in basal beating rate after 7 mins by inverted microscopic method | Rattus norvegicus | 4 | ALA4414645 | cell-based format | Scientific Literature | |
7. | ALA4416905 | F | Negative chronotropic activity in Wistar rat neonatal cardiomyocytes assessed as changes to basal beating rate after 7 mins by inverted microscopic method | Rattus norvegicus | 4 | ALA4414645 | cell-based format | Scientific Literature | |
8. | ALA4416906 | P | Aqueous solubility of the compound in pH 7.4 potassium phosphate buffer at 2 mg after 1 to 24 hrs by RP-HPLC method | 6 | ALA4414645 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4416907 | P | n-Octanol-Tris/phosphoric acid buffer buffer distribution coefficient, log D of the compound at pH 7.4 shaken for 30 mins and measured after 24 hrs by UV-HPLC method | 3 | ALA4414645 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4416908 | A | Stability in human plasma at 10 uM measured over 240 mins by LC-ESI-MS/MS analysis | Homo sapiens | 3 | ALA4414645 | cell-free format | Scientific Literature | |
11. | ALA4416910 | A | Protein binding in human plasma at 10 uM incubated for 60 mins by LC-ESI-MS/MS analysis | Homo sapiens | 4 | ALA4414645 | cell-free format | Scientific Literature | |
12. | ALA4416911 | A | Intrinsic clearance in human hepatocytes assessed per million cells at 1 uM measured up to 180 mins by LC-ESI-MS/MS analysis | Homo sapiens | 4 | ALA4414645 | cell-based format | Scientific Literature | |
13. | ALA4416912 | A | Half life in human hepatocytes at 1 uM measured up to 180 mins by LC-ESI-MS/MS analysis | Homo sapiens | 4 | ALA4414645 | cell-based format | Scientific Literature | |
14. | ALA4416913 | P | Stability of compound in HEPES buffer assessed as parent compound remaining at 1 uM after 180 mins by LC-ESI-MS/MS analysis | 3 | ALA4414645 | small-molecule physicochemical format | Scientific Literature | ||
15. | ALA4416914 | A | Inhibition of human CYP1A2 by fluorescence method | Homo sapiens | 4 | ALA4414645 | single protein format | Scientific Literature | |
16. | ALA4416915 | A | Inhibition of human CYP2B6 by fluorescence method | Homo sapiens | 4 | ALA4414645 | single protein format | Scientific Literature | |
17. | ALA4416916 | A | Inhibition of human CYP2C8 by fluorescence method | Homo sapiens | 4 | ALA4414645 | single protein format | Scientific Literature | |
18. | ALA4416917 | A | Inhibition of human CYP2C9 by fluorescence method | Homo sapiens | 4 | ALA4414645 | single protein format | Scientific Literature | |
19. | ALA4416918 | A | Inhibition of human CYP2C19 by fluorescence method | Homo sapiens | 4 | ALA4414645 | single protein format | Scientific Literature | |
20. | ALA4416919 | A | Inhibition of human CYP2D6 by fluorescence method | Homo sapiens | 4 | ALA4414645 | single protein format | Scientific Literature |